LipidDB-9606-01300

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01300

Entry Name

FSHR_HUMAN

UniProt Accession

P23945; A8K947; G5CBS7; G5E967; J3KQ00; Q05AH0; Q16225; Q4QRJ3; Q4ZFZ2; Q53RW2;

Theoretical PI

6.77

Molecular Weight

78265.01

Genbank Protein ID

AAA52477.1; AAA52478.1; AAB26480.1; AEI86722.1; AAR07899.1; BAF85251.1; AAX93229.1; AAX88895.1; EAX00188.1; EAX00189.1; AAH96831.1; AAI18549.1; AAI25271.1; CAA48179.1; AAB32071.1; AAB32225.1;

Genbank Nucleotide ID

M65085; M95489; S59900; JN003607; AY429104; AK292562; AC007189; AC079394; AC092533; CH471053; CH471053; BC096831; BC118548; BC125270; X68044; S73199; S73526;

Protein Name

Follicle-stimulating hormone receptor

Protein Synonyms/Alias

FSH-R; Follitropin receptor;

Gene Name

FSHR

Gene Synonyms/Alias

LGR1;

Created Date

01-MAR-1992

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
644	Canonical	FFILLSKCGCYEMQA	[1]	S-Palmitoylation
646	Canonical	ILLSKCGCYEMQAQI	[1]	S-Palmitoylation
672	Canonical	THPRNGHCSSAPRVT	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Uribe A, Zariñán T, Pérez-Solis MA, Gutiérrez-Sagal R, Jardón-Valadez E,Piñeiro A, Dias JA, Ulloa-Aguirre A. Functional and structural roles of conservedcysteine residues in the carboxyl-terminal domain of the follicle-stimulatinghormone receptor in human embryonic kidney 293 cells. Biol Reprod. 2008May;78(5):869-82. doi: 10.1095/biolreprod.107.063925. Epub 2008 Jan 16. PubMedPMID: 18199880.[PMID:18199880]

Functional Description

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Sequence Annotation

Topological domain: 18 366 Extracellular.
Transmembrane: 367 387 Helical; Name=1.
Topological domain: 388 398 Cytoplasmic.
Transmembrane: 399 421 Helical; Name=2.
Topological domain: 422 443 Extracellular.
Transmembrane: 444 465 Helical; Name=3.
Topological domain: 466 485 Cytoplasmic.
Transmembrane: 486 508 Helical; Name=4.
Topological domain: 509 528 Extracellular.
Transmembrane: 529 550 Helical; Name=5.
Topological domain: 551 573 Cytoplasmic.
Transmembrane: 574 597 Helical; Name=6.
Topological domain: 598 608 Extracellular.
Transmembrane: 609 630 Helical; Name=7.
Topological domain: 631 695 Cytoplasmic.
Domain: 18 46 LRRNT.

Protein Length

695 AA.

Protein Sequence
(Canonical)

MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV  60
IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP  120
NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN  180
GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN  240
LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE  300
VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM  360
GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS  420
VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK  480
VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL  540
AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP  600
LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS  660
TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN                             695

FASTA
(Canonical)

>LipidDB-9606-01300|P23945
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRV
IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLP
NLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN
GIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLEN
LKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQE
VDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIM
GYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIAS
VDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCK
VQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVL
AFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVP
LITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSS
TVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN

Gene Ontology

GO:0016021; C:integral component of membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004963; F:follicle-stimulating hormone receptor activity; TAS:ProtInc
GO:0007292; P:female gamete generation; TAS:ProtInc
GO:0008585; P:female gonad development; TAS:ProtInc
GO:0042699; P:follicle-stimulating hormone signaling pathway; TAS:GOC
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0008406; P:gonad development; TAS:ProtInc
GO:0008584; P:male gonad development; IEP:UniProtKB
GO:0007283; P:spermatogenesis; TAS:ProtInc

Interpro

InterPro; IPR002272; FSH_rcpt
InterPro; IPR024635; GnHR_TM
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR002131; Gphrmn_rcpt_fam
InterPro; IPR001611; Leu-rich_rpt
InterPro; IPR000372; LRR-contain_N

Pfam

Pfam; PF00001; 7tm_1;
Pfam; PF12369; GnHR_trans;
Pfam; PF13855; LRR_8;
Pfam; PF01462; LRRNT;

SMART

SMART; SM00013; LRRNT;

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR01143; FSHRECEPTOR;
PRINTS; PR00373; GLYCHORMONER;
PRINTS; PR00237; GPCRRHODOPSN;