LipidDB-9606-01294

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01294

Entry Name

CTL1_HUMAN

UniProt Accession

Q8WWI5; A6NLZ9; Q5VUB3; Q8WVB0; Q96KU3; Q9NY69;

Theoretical PI

8.93

Molecular Weight

73302.11

Genbank Protein ID

CAB75541.2; CAC82175.1; CAD12764.1; CAI13069.1; CAI13069.1; CAI13069.1; CAI13070.1; CAI13070.1; CAI13070.1; CAI13071.1; CAI13071.1; CAI13071.1; CAI14395.1; CAI14395.1; CAI14395.1; CAI14396.1; CAI14396.1; CAI14396.1; CAI14397.1; CAI14397.1; CAI14397.1; CAH73434.1; CAH73434.1; CAH73434.1; CAH73435.1; CAH73435.1; CAH73435.1; CAH73436.1; CAH73436.1; CAH73436.1; AAH18213.1; AAH49203.1;

Genbank Nucleotide ID

AJ245620; AJ272365; AJ420812; AL161627; AL450265; AL590368; AL161627; AL450265; AL590368; AL161627; AL450265; AL590368; AL450265; AL161627; AL590368; AL450265; AL161627; AL590368; AL450265; AL161627; AL590368; AL590368; AL161627; AL450265; AL590368; AL161627; AL450265; AL590368; AL161627; AL450265; BC018213; BC049203;

Protein Name

Choline transporter-like protein 1

Protein Synonyms/Alias

CDw92; Solute carrier family 44 member 1; CD92;

Gene Name

SLC44A1

Gene Synonyms/Alias

CD92; CDW92; CTL1;

Created Date

30-AUG-2005

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
3	Canonical	*****MGCCSSASSA	[1]	S-Palmitoylation
4	Canonical	****MGCCSSASSAA	[1]	S-Palmitoylation
402	Canonical	ISEFILACQQMTVAG	[1]	S-Palmitoylation
477	Canonical	KENACARCVLKSCIC	[1]	S-Palmitoylation
482	Canonical	ARCVLKSCICCLWCL	[1]	S-Palmitoylation
485	Canonical	VLKSCICCLWCLEKC	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Choline transporter. May be involved in membrane synthesis and myelin production.

Sequence Annotation

Topological domain: 2 30 Cytoplasmic.
Transmembrane: 31 51 Helical.
Topological domain: 52 212 Mitochondrial intermembrane.
Transmembrane: 213 233 Helical.
Topological domain: 234 238 Cytoplasmic.
Transmembrane: 239 259 Helical.
Topological domain: 260 288 Mitochondrial intermembrane.
Transmembrane: 289 309 Helical.
Topological domain: 310 315 Cytoplasmic.
Transmembrane: 316 336 Helical.
Topological domain: 337 338 Mitochondrial intermembrane.
Transmembrane: 339 359 Helical.
Topological domain: 360 380 Cytoplasmic.
Transmembrane: 381 401 Helical.
Topological domain: 402 537 Mitochondrial intermembrane.
Transmembrane: 538 558 Helical.
Topological domain: 559 566 Cytoplasmic.
Transmembrane: 567 587 Helical.
Topological domain: 588 653 Mitochondrial intermembrane.
Modified residue: 652 652 Phosphoserine.

Protein Length

657 AA.

Protein Sequence
(Canonical)

MGCCSSASSA AQSSKREWKP LEDRSCTDIP WLLLFILFCI GMGFICGFSI ATGAAARLVS  60
GYDSYGNICG QKNTKLEAIP NSGMDHTQRK YVFFLDPCNL DLINRKIKSV ALCVAACPRQ  120
ELKTLSDVQK FAEINGSALC SYNLKPSEYT TSPKSSVLCP KLPVPASAPI PFFHRCAPVN  180
ISCYAKFAEA LITFVSDNSV LHRLISGVMT SKEIILGLCL LSLVLSMILM VIIRYISRVL  240
VWILTILVIL GSLGGTGVLW WLYAKQRRSP KETVTPEQLQ IAEDNLRALL IYAISATVFT  300
VILFLIMLVM RKRVALTIAL FHVAGKVFIH LPLLVFQPFW TFFALVLFWV YWIMTLLFLG  360
TTGSPVQNEQ GFVEFKISGP LQYMWWYHVV GLIWISEFIL ACQQMTVAGA VVTYYFTRDK  420
RNLPFTPILA SVNRLIRYHL GTVAKGSFII TLVKIPRMIL MYIHSQLKGK ENACARCVLK  480
SCICCLWCLE KCLNYLNQNA YTATAINSTN FCTSAKDAFV ILVENALRVA TINTVGDFML  540
FLGKVLIVCS TGLAGIMLLN YQQDYTVWVL PLIIVCLFAF LVAHCFLSIY EMVVDVLFLC  600
FAIDTKYNDG SPGREFYMDK VLMEFVENSR KAMKEAGKGG VADSRELKPM ASGASSA     657

FASTA
(Canonical)

>LipidDB-9606-01294|Q8WWI5
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVS
GYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQ
ELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVN
ISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVL
VWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFT
VILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLG
TTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK
RNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLK
SCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFML
FLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLC
FAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; TAS:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0015220; F:choline transmembrane transporter activity; TAS:UniProtKB
GO:0015871; P:choline transport; TAS:UniProtKB
GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome
GO:0006656; P:phosphatidylcholine biosynthetic process; TAS:Reactome
GO:0006644; P:phospholipid metabolic process; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR007603; Choline_transptr-like

Pfam

Pfam; PF04515; Choline_transpo;

SMART

PROSITE

PRINTS