LipidDB ID

LipidDB-9606-01293

Entry Name

UniProt Accession

P08559; A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5;

Theoretical PI

8.35

Molecular Weight

43295.63

Genbank Protein ID

BAA14121.1; AAA36533.1; CAA36933.1; CAA36934.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60051.1; AAA60227.1; AAA60055.1; AAA60050.1; AAB59581.1; ABQ59099.1; BAH11476.1; BAH12361.1; BAG35194.1; BAH12323.1; BAD96460.1; CAI41291.1; EAW98960.1; AAH02406.1; AAD23841.1; AAD23842.1; AAD23843.1; AAD23844.1; AAD23845.1; AAD23846.1; AAD23847.1; AAD23848.1; AAD23849.1; AAD23850.1; AAD23851.1; AAD23852.1; AAD23853.1; AAD23854.1; AAD23855.1; AAD23856.1; AAD23857.1; AAD23858.1; AAD23859.1; AAD23860.1; AAD23861.1; AAD23862.1; AAD23863.1; AAD23864.1; AAD23866.1; AAD23867.1; AAD23868.1; AAD23869.1; AAD23870.1; AAD23871.1; AAD23872.1; AAD23873.1; AAD23874.1; AAD23875.1; AAD23876.1;

Genbank Nucleotide ID

D90084; M24848; X52709; X52710; M27257; M29155; M29156; M29157; M29158; M29159; M29160; M29161; M29162; M29163; M29164; L13318; J03503; J03575; L48690; EF590117; AK293250; AK296457; AK312263; AK296341; AK222740; AL732326; CH471074; BC002406; AF125053; AF125054; AF125055; AF125056; AF125057; AF125058; AF125059; AF125060; AF125061; AF125062; AF125063; AF125064; AF125065; AF125066; AF125067; AF125068; AF125069; AF125070; AF125071; AF125072; AF125073; AF125074; AF125075; AF125076; AF125078; AF125079; AF125080; AF125081; AF125082; AF125083; AF125084; AF125085; AF125086; AF125087; AF125088;

Protein Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Protein Synonyms/Alias

1.2.4.1; PDHE1-A type I;

Gene Name

PDHA1

Gene Synonyms/Alias

PHE1A;

Created Date

01-AUG-1988

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Sequence Annotation

Modified residue: 63 63 N6-acetyllysine; alternate.
Modified residue: 63 63 N6-succinyllysine; alternate.
Modified residue: 232 232 Phosphoserine; by PDK1.
Modified residue: 244 244 N6-acetyllysine; alternate.
Modified residue: 244 244 N6-succinyllysine; alternate.
Modified residue: 277 277 N6-succinyllysine.
Modified residue: 293 293 Phosphoserine; by PDK1, PDK2, PDK3 andPDK4.
Modified residue: 295 295 Phosphoserine.
Modified residue: 300 300 Phosphoserine; by PDK1, PDK2, PDK3 andPDK4.
Modified residue: 301 301 Phosphotyrosine.
Modified residue: 313 313 N6-acetyllysine; alternate.
Modified residue: 313 313 N6-succinyllysine; alternate.
Modified residue: 321 321 N6-acetyllysine.
Modified residue: 336 336 N6-acetyllysine.
Modified residue: 385 385 N6-succinyllysine.

Protein Length

390 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005759; C:mitochondrial matrix; TAS:Reactome
GO:0005739; C:mitochondrion; IDA:UniProt
GO:0005634; C:nucleus; IDA:UniProt
GO:0045254; C:pyruvate dehydrogenase complex; IDA:UniProtKB
GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC
GO:0004738; F:pyruvate dehydrogenase activity; IDA:UniProtKB
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:UniProtKB
GO:0044237; P:cellular metabolic process; TAS:Reactome
GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW
GO:0006096; P:glycolytic process; IEA:InterPro
GO:0006090; P:pyruvate metabolic process; TAS:Reactome
GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0006099; P:tricarboxylic acid cycle; IDA:UniProtKB

Interpro

InterPro; IPR001017; DH_E1
InterPro; IPR017597; Pyrv_DH_E1_asu_subgrp-y
InterPro; IPR029061; THDP-binding

Pfam

Pfam; PF00676; E1_dh;

SMART

PROSITE

PRINTS