Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01264
Entry Name
UniProt Accession
Theoretical PI
4.81
Molecular Weight
25059.67
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Eukaryotic translation initiation factor 3 subunit K
Protein Synonyms/Alias
eIF3k; Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; PLAC-24; eIF-3 p25; eIF-3 p28;
Gene Name
EIF3K
Gene Synonyms/Alias
EIF3S12; ARG134; HSPC029; MSTP001; PTD001;
Created Date
19-SEP-2002
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
85
Canonical
PHTDFTLCKCMIDQA
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Sequence Annotation
Modified residue: 2 2 N-acetylalanine.
Modified residue: 217 217 Phosphoserine.
Protein Length
218 AA.
Protein Sequence
(Canonical)
MAMFEQMRAN VGKLLKGIDR YNPENLATLE RYVETQAKEN AYDLEANLAV LKLYQFNPAF  60
FQTTVTAQIL LKALTNLPHT DFTLCKCMID QAHQEERPIR QILYLGDLLE TCHFQAFWQA  120
LDENMDLLEG ITGFEDSVRK FICHVVGITY QHIDRWLLAE MLGDLSDSQL KVWMSKYGWS  180
ADESGQIFIC SQEESIKPKN IVEKIDFDSV SSIMASSQ                          218
FASTA
(Canonical)
>LipidDB-9606-01264|Q9UBQ5
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAF
FQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQA
LDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWS
ADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-HAMAP
GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-HAMAP
GO:0005852; C:eukaryotic translation initiation factor 3 complex; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0043022; F:ribosome binding; IEA:InterPro
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-HAMAP
GO:0044267; P:cellular protein metabolic process; TAS:Reactome
GO:0001731; P:formation of translation preinitiation complex; IEA:UniProtKB-HAMAP
GO:0010467; P:gene expression; TAS:Reactome
GO:0006446; P:regulation of translational initiation; IEA:UniProtKB-HAMAP
GO:0006412; P:translation; TAS:Reactome
GO:0006413; P:translational initiation; IDA:UniProtKB
Interpro
InterPro; IPR016024; ARM-type_fold
InterPro; IPR009374; eIF3k
InterPro; IPR016020; Transl_init_fac_sub12_N_euk
InterPro; IPR011991; WHTH_DNA-bd_dom
Pfam
SMART
PROSITE
PRINTS