Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01247
Entry Name
UniProt Accession
Theoretical PI
5.04
Molecular Weight
30606.61
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Interleukin-1 alpha
Protein Synonyms/Alias
IL-1 alpha; Hematopoietin-1;
Gene Name
IL1A
Gene Synonyms/Alias
IL1F1;
Created Date
21-JUL-1986
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
82
Canonical
ATNGKVLKKRRLSLS
[1]
N-Myristoylation
83
Canonical
TNGKVLKKRRLSLSQ
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. The 31-kDaprecursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7245-9.[PMID:8346241]
Functional Description
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Sequence Annotation
Modified residue: 87 87 Phosphoserine.
Protein Length
271 AA.
Protein Sequence
(Canonical)
MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ SVSLSISETS  60
KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI ANDSEEEIIK PRSAPFSFLS  120
NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI  180
TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP  240
NLFIATKQDY WVCLAGGPPS ITDFQILENQ A                                 271
FASTA
(Canonical)
>LipidDB-9606-01247|P01583
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETS
KTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLS
NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKI
TVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHP
NLFIATKQDYWVCLAGGPPSITDFQILENQA
Gene Ontology
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0005576; C:extracellular region; TAS:Reactome
GO:0005615; C:extracellular space; IDA:UniProtKB
GO:0005507; F:copper ion binding; IDA:UniProtKB
GO:0005125; F:cytokine activity; IMP:BHF-UCL
GO:0006915; P:apoptotic process; TAS:ProtInc
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0034605; P:cellular response to heat; IDA:UniProtKB
GO:0019221; P:cytokine-mediated signaling pathway; IMP:BHF-UCL
GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl
GO:0001660; P:fever generation; IEA:UniProtKB-KW
GO:0006955; P:immune response; IEA:InterPro
GO:0006954; P:inflammatory response; TAS:ProtInc
GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL
GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; TAS:BHF-UCL
GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW
GO:0050715; P:positive regulation of cytokine secretion; IDA:BHF-UCL
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IMP:BHF-UCL
GO:0045840; P:positive regulation of mitosis; IMP:BHF-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0010575; P:positive regulation vascular endothelial growth factor production; ISS:BHF-UCL
GO:0046688; P:response to copper ion; IDA:UniProtKB
Interpro
InterPro; IPR008996; Cytokine_IL1-like
InterPro; IPR003295; IL-1_alpha
InterPro; IPR003294; IL-1_alpha/beta
InterPro; IPR020877; IL-1_CS
InterPro; IPR000975; IL-1_fam
InterPro; IPR003502; IL-1_propep
Pfam
Pfam; PF00340; IL1;
Pfam; PF02394; IL1_propep;
SMART
PROSITE
PROSITE; PS00253; INTERLEUKIN_1;
PRINTS
PRINTS; PR00264; INTERLEUKIN1;
PRINTS; PR01358; INTRLEUKIN1A;
PRINTS; PR01357; INTRLEUKN1AB;