LipidDB ID

LipidDB-9606-01245

Entry Name

UniProt Accession

Q99714; Q5H927; Q6IBS9; Q8TCV9; Q96HD5;

Theoretical PI

7.65

Molecular Weight

26923.08

Genbank Protein ID

AAC51812.1; AAB68958.1; AAC39900.1; AAC15902.1; AAC16419.1; CAG33004.1; CAI42652.1; CAI42653.1; EAW93157.1; EAW93158.1; AAH00372.1; AAH08708.1; AAM18189.1;

Genbank Nucleotide ID

U96132; U73514; AF069134; AF035555; AF037438; CR456723; Z97054; Z97054; CH471154; CH471154; BC000372; BC008708; AY092415;

Protein Name

3-hydroxyacyl-CoA dehydrogenase type-2

Protein Synonyms/Alias

1.1.1.35; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 1.1.1.51; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 1.1.1.178; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; Mitochondrial ribonuclease P protein 2; Mitochondrial RNase P protein 2; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH;

Gene Name

HSD17B10

Gene Synonyms/Alias

ERAB; HADH2; MRPP2; SCHAD; XH98G2;

Created Date

01-NOV-1997

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Sequence Annotation

Nucleotide-binding: 12 41 NAD.
Active site: 168 168 Proton acceptor.
Binding site: 155 155 Substrate.
Binding site: 172 172 NAD.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 53 53 N6-acetyllysine; alternate.
Modified residue: 53 53 N6-succinyllysine; alternate.
Modified residue: 69 69 N6-acetyllysine.
Modified residue: 99 99 N6-acetyllysine.
Modified residue: 105 105 N6-acetyllysine.
Modified residue: 212 212 N6-acetyllysine; alternate.
Modified residue: 212 212 N6-succinyllysine; alternate.

Protein Length

261 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; TAS:ProtInc
GO:0005783; C:endoplasmic reticulum; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl
GO:0005759; C:mitochondrial matrix; TAS:Reactome
GO:0005739; C:mitochondrion; ISS:UniProtKB
GO:0005886; C:plasma membrane; TAS:ProtInc
GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC
GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; EXP:Reactome
GO:0008709; F:cholate 7-alpha-dehydrogenase activity; TAS:ProtInc
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB
GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; IEA:UniProtKB-EC
GO:0009083; P:branched-chain amino acid catabolic process; TAS:Reactome
GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome
GO:0006629; P:lipid metabolic process; TAS:ProtInc
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0008033; P:tRNA processing; IEA:UniProtKB-KW

Interpro

InterPro; IPR002198; DH_sc/Rdtase_SDR
InterPro; IPR002347; Glc/ribitol_DH
InterPro; IPR016040; NAD(P)-bd_dom
InterPro; IPR020904; Sc_DH/Rdtase_CS

Pfam

Pfam; PF00106; adh_short;

SMART

PROSITE

PROSITE; PS00061; ADH_SHORT;

PRINTS

PRINTS; PR00081; GDHRDH;
PRINTS; PR00080; SDRFAMILY;