LipidDB ID

LipidDB-9606-01229

Entry Name

UniProt Accession

P60709; P02570; P70514; P99021; Q11211; Q64316; Q75MN2; Q96B34; Q96HG5;

Theoretical PI

5.29

Molecular Weight

41736.73

Genbank Protein ID

CAA25099.1; AAA51567.1; CAA45026.1; AAS79319.1; AAP22343.1; AAH01301.1; AAH02409.1; AAH04251.1; AAH08633.1; AAH12854.1; AAH13380.1; AAH14861.1; AAH16045.1; CAA23745.1;

Genbank Nucleotide ID

X00351; M10277; X63432; AY582799; AC006483; BC001301; BC002409; BC004251; BC008633; BC012854; BC013380; BC014861; BC016045; V00478;

Protein Name

Actin, cytoplasmic 1, N-terminally processed

Protein Synonyms/Alias

Beta-actin;

Gene Name

ACTB

Gene Synonyms/Alias

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Utsumi T, Sakurai N, Nakano K, Ishisaka R. C-terminal 15 kDa fragment ofcytoskeletal actin is posttranslationally N-myristoylated upon caspase-mediatedcleavage and targeted to mitochondria. FEBS Lett. 2003 Mar 27;539(1-3):37-44.[PMID:12650923]

Functional Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Sequence Annotation

Modified residue: 1 1 N-acetylmethionine.
Modified residue: 2 2 N-acetylaspartate; in Actin, cytoplasmic1, N-terminally processed.
Modified residue: 44 44 Methionine (R)-sulfoxide.
Modified residue: 47 47 Methionine (R)-sulfoxide.
Modified residue: 73 73 Tele-methylhistidine.
Modified residue: 84 84 N6-methyllysine.

Protein Length

375 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IEA:Ensembl
GO:0072562; C:blood microparticle; IDA:UniProt
GO:0030863; C:cortical cytoskeleton; IEA:Ensembl
GO:0005737; C:cytoplasm; TAS:UniProtKB
GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL
GO:0005856; C:cytoskeleton; TAS:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0005615; C:extracellular space; IDA:UniProt
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0070688; C:MLL5-L complex; IDA:UniProtKB
GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB
GO:0000790; C:nuclear chromatin; IDA:UniProt
GO:0005654; C:nucleoplasm; TAS:Reactome
GO:0014069; C:postsynaptic density; IEA:Ensembl
GO:0043234; C:protein complex; IDA:UniProt
GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0019894; F:kinesin binding; IPI:UniProtKB
GO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL
GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB
GO:0030957; F:Tat protein binding; IPI:BHF-UCL
GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome
GO:0034332; P:adherens junction organization; TAS:Reactome
GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProt
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0034329; P:cell junction assembly; TAS:Reactome
GO:0045216; P:cell-cell junction organization; TAS:Reactome
GO:0006928; P:cellular component movement; TAS:UniProtKB
GO:0044267; P:cellular protein metabolic process; TAS:Reactome
GO:0006325; P:chromatin organization; TAS:Reactome
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome
GO:0045087; P:innate immune response; TAS:Reactome
GO:0061024; P:membrane organization; TAS:Reactome
GO:0070527; P:platelet aggregation; IMP:UniProtKB
GO:0006457; P:protein folding; TAS:Reactome
GO:0001895; P:retina homeostasis; IEP:UniProt
GO:0021762; P:substantia nigra development; IEP:UniProt

Interpro

InterPro; IPR004000; Actin-related
InterPro; IPR020902; Actin/actin-like_CS
InterPro; IPR004001; Actin_CS

Pfam

Pfam; PF00022; Actin;

SMART

SMART; SM00268; ACTIN;

PROSITE

PROSITE; PS00406; ACTINS_1;
PROSITE; PS00432; ACTINS_2;
PROSITE; PS01132; ACTINS_ACT_LIKE;

PRINTS

PRINTS; PR00190; ACTIN;