LipidDB ID

LipidDB-9606-01221

Entry Name

UniProt Accession

Q13286; B2R7J1; O00668; O95089; Q549S9; Q9UP09; Q9UP11; Q9UP12; Q9UP13; Q9UP14;

Theoretical PI

5.93

Molecular Weight

47622.99

Genbank Protein ID

AAB51075.1; CAA68148.1; AAD01555.1; AAD01560.1; AAD51478.1; AAD51479.1; AAD51480.1; AAD51481.1; AAD51483.1; AAD51484.1; AAD51488.1; AAD51482.1; AAD51485.1; AAD51487.1; AAD51493.1; AAD51494.1; AAD48543.1; BAG35838.1; AAC05337.1; AAC27430.1; EAW52281.1; EAW52286.1; AAH02394.1; AAH04433.1;

Genbank Nucleotide ID

U32680; X99832; AF015593; AF015598; AF077956; AF077957; AF077958; AF077959; AF077961; AF077962; AF077966; AF077960; AF077963; AF077965; AF077971; AF077972; AF078169; AK313002; AC002425; AC002544; AC138894; CH471279; CH471279; BC002394; BC004433;

Protein Name

Battenin

Protein Synonyms/Alias

Batten disease protein; Protein CLN3;

Gene Name

CLN3

Gene Synonyms/Alias

BTS;

Created Date

01-NOV-1997

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Pullarkat RK, Morris GN. Farnesylation of Batten disease CLN3 protein.Neuropediatrics. 1997 Feb;28(1):42-4.[PMID:9151320]
[2] Storch S, Pohl S, Quitsch A, Falley K, Braulke T. C-terminal prenylation ofthe CLN3 membrane glycoprotein is required for efficient endosomal sorting tolysosomes. Traffic. 2007 Apr;8(4):431-44. Epub 2007 Feb 7.[PMID:17286803]

Functional Description

Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.

Sequence Annotation

Topological domain: 1 37 Cytoplasmic.
Transmembrane: 38 58 Helical.
Topological domain: 59 127 Lumenal.
Transmembrane: 128 148 Helical.
Topological domain: 149 151 Cytoplasmic.
Transmembrane: 152 172 Helical.
Topological domain: 173 182 Lumenal.
Transmembrane: 183 203 Helical.
Topological domain: 204 277 Cytoplasmic.
Transmembrane: 278 298 Helical.
Topological domain: 299 346 Lumenal.
Transmembrane: 347 367 Helical.
Topological domain: 368 438 Cytoplasmic.
Modified residue: 12 12 Phosphoserine.
Modified residue: 14 14 Phosphoserine.
Modified residue: 435 435 Cysteine methyl ester.

Protein Length

438 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005776; C:autophagic vacuole; ISS:UniProtKB
GO:0005901; C:caveola; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005769; C:early endosome; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0000139; C:Golgi membrane; IDA:UniProtKB
GO:0005795; C:Golgi stack; IDA:UniProtKB
GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB
GO:0016021; C:integral component of membrane; IDA:UniProtKB
GO:0005770; C:late endosome; IDA:UniProtKB
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0005764; C:lysosome; IDA:UniProtKB
GO:0045121; C:membrane raft; IDA:UniProtKB
GO:0005739; C:mitochondrion; TAS:ProtInc
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0008021; C:synaptic vesicle; IDA:UniProtKB
GO:0005802; C:trans-Golgi network; IDA:UniProtKB
GO:0051082; F:unfolded protein binding; TAS:ProtInc
GO:0001508; P:action potential; ISS:UniProtKB
GO:0042987; P:amyloid precursor protein catabolic process; IDA:UniProtKB
GO:0015809; P:arginine transport; IDA:UniProtKB
GO:0008306; P:associative learning; ISS:UniProtKB
GO:0000046; P:autophagic vacuole fusion; ISS:UniProtKB
GO:0008219; P:cell death; IEA:UniProtKB-KW
GO:0006520; P:cellular amino acid metabolic process; ISS:UniProtKB
GO:0006672; P:ceramide metabolic process; IDA:UniProtKB
GO:0051480; P:cytosolic calcium ion homeostasis; ISS:UniProtKB
GO:0006681; P:galactosylceramide metabolic process; IMP:UniProtKB
GO:0001575; P:globoside metabolic process; IMP:UniProtKB
GO:0006678; P:glucosylceramide metabolic process; IMP:UniProtKB
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB
GO:0007042; P:lysosomal lumen acidification; IMP:UniProtKB
GO:0035752; P:lysosomal lumen pH elevation; IDA:UniProtKB
GO:0007040; P:lysosome organization; ISS:UniProtKB
GO:0016236; P:macroautophagy; NAS:UniProtKB
GO:0061024; P:membrane organization; ISS:UniProtKB
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB
GO:0043086; P:negative regulation of catalytic activity; ISS:UniProtKB
GO:0016242; P:negative regulation of macroautophagy; ISS:UniProtKB
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB
GO:0045861; P:negative regulation of proteolysis; ISS:UniProtKB
GO:0050885; P:neuromuscular process controlling balance; ISS:UniProtKB
GO:0042133; P:neurotransmitter metabolic process; ISS:UniProtKB
GO:0030163; P:protein catabolic process; NAS:UniProtKB
GO:0016485; P:protein processing; ISS:UniProtKB
GO:0006898; P:receptor-mediated endocytosis; IMP:UniProtKB
GO:0006684; P:sphingomyelin metabolic process; IMP:UniProtKB
GO:0007034; P:vacuolar transport; IBA:RefGenome
GO:0047496; P:vesicle transport along microtubule; IMP:UniProtKB

Interpro

InterPro; IPR003492; Battenin_disease_Cln3
InterPro; IPR018460; Battenin_disease_Cln3_subgr
InterPro; IPR016196; MFS_dom_general_subst_transpt

Pfam

Pfam; PF02487; CLN3;

SMART

PROSITE

PRINTS

PRINTS; PR01315; BATTENIN;