| Tag |
Content |
LipidDB ID |
LipidDB-9606-01216 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.14 |
Molecular Weight |
29625.52 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
CD82 antigen |
Protein Synonyms/Alias |
C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD82; |
Gene Name |
CD82 |
Gene Synonyms/Alias |
KAI1; SAR2; ST6; TSPAN27; |
Created Date |
01-AUG-1992 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
5 | Canonical | ***MGSACIKVTKYF | [1] | S-Palmitoylation | 74 | Canonical | MLMGFLGCIGAVNEV | [1] | S-Palmitoylation | 83 | Canonical | GAVNEVRCLLGLYFA | [1] | S-Palmitoylation | 251 | Canonical | LGMVLSICLCRHVHS | [1] | S-Palmitoylation | 253 | Canonical | MVLSICLCRHVHSED | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Zhou B, Liu L, Reddivari M, Zhang XA. The palmitoylation of metastasissuppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitoryactivity. Cancer Res. 2004 Oct 15;64(20):7455-63.[ PMID:15492270]
|
Functional Description |
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. |
Sequence Annotation |
Topological domain: 1 11 Cytoplasmic.
Transmembrane: 12 32 Helical.
Topological domain: 33 53 Extracellular.
Transmembrane: 54 72 Helical.
Topological domain: 73 83 Cytoplasmic.
Transmembrane: 84 110 Helical.
Topological domain: 111 228 Extracellular.
Transmembrane: 229 250 Helical.
Topological domain: 251 267 Cytoplasmic.
|
Protein Length |
267 AA. |
Protein Sequence
(Canonical) |
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS SLRMGAYVFI 60
GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV TAGALFYFNM GKLKQEMGGI 120
VTELIRDYNS SREDSLQDAW DYVQAQVKCC GWVSFYNWTD NAELMNRPEV TYPCSCEVKG 180
EEDNSLSVRK GFCEAPGNRT QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI 240
IELLGMVLSI CLCRHVHSED YSKVPKY 267
|
FASTA
(Canonical) |
>LipidDB-9606-01216|P27701
MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISVLQTSSSSLRMGAYVFI
GVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGI
VTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKG
EEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAI
IELLGMVLSICLCRHVHSEDYSKVPKY
|
Gene Ontology |
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt GO:0005887; C:integral component of plasma membrane; TAS:ProtInc GO:0005886; C:plasma membrane; TAS:ProtInc |
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|