LipidDB-9606-01204

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01204

Entry Name

UniProt Accession

Q14126; Q4KKU6;

Theoretical PI

5.13

Molecular Weight

122293.92

Genbank Protein ID

CAA81226.1; AAH99655.1; AAH99656.1; AAH99657.1;

Genbank Nucleotide ID

Z26317; BC099655; BC099656; BC099657;

Protein Name

Desmoglein-2

Protein Synonyms/Alias

Cadherin family member 5; HDGC;

Gene Name

DSG2

Gene Synonyms/Alias

CDHF5;

Created Date

01-NOV-1997

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
635	Canonical	VPLLLLMCHCGKGAK	[1]	S-Palmitoylation
637	Canonical	LLLLMCHCGKGAKGF	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Sequence Annotation

Topological domain: 50 609 Extracellular.
Transmembrane: 610 634 Helical.
Topological domain: 635 1118 Cytoplasmic.
Domain: 50 160 Cadherin 1.
Domain: 161 273 Cadherin 2.
Domain: 274 388 Cadherin 3.
Domain: 389 503 Cadherin 4.
Modified residue: 680 680 Phosphoserine.
Modified residue: 703 703 Phosphoserine.
Modified residue: 1118 1118 Phosphoserine.

Protein Length

1118 AA.

Protein Sequence
(Canonical)

MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE  60
GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE  120
ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK  180
INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE  240
ARDGNGEVTD KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE  300
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF SVIVANKAAF  360
HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES MDRSSKGQII GNFQAFDEDT  420
GLPAHARYVK LEDRDNWISV DSVTSEIKLA KLPDFESRYV QNGTYTVKIV AISEDYPRKT  480
ITGTVLINVE DINDNCPTLI EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM  540
AEKWKIARQE STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR  600
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT IEMLHPWNNE  660
GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS SASIVKGQHE MSEMDGRWEE  720
HRSLLSGRAT QFTGATGAIM TTETTKTARA TGASRDMAGA QAAAVALNEE FLRNYFTDKA  780
ASYTEEDENH TAKDCLLVYS QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC  840
LGQKIDINKE IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE  900
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT VILGPSQPQS  960
LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN PLEGTQHLQD VPYVMVRERE  1020
SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV LAPASTLQSS YQIPTENSMT ARNTTVSGAG  1080
VPGPLPDFGL EESGHSNSTI TTSSTRVTKH STVQHSYS                          1118

FASTA
(Canonical)

>LipidDB-9606-01204|Q14126
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALRE
GEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDRE
ETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMK
INATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVE
ARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADE
IGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAF
HKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDT
GLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKT
ITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGM
AEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCR
EAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNE
GAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEE
HRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKA
ASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVC
LGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAE
KVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQS
LIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERE
SFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAG
VPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005911; C:cell-cell junction; TAS:ProtInc
GO:0030057; C:desmosome; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0016328; C:lateral plasma membrane; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:UniProt
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0006915; P:apoptotic process; TAS:Reactome
GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL
GO:0007155; P:cell adhesion; IDA:UniProtKB
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome
GO:0007156; P:homophilic cell adhesion; IEA:InterPro
GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl
GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL
GO:0032570; P:response to progesterone; IEA:Ensembl
GO:0086005; P:ventricular cardiac muscle cell action potential; IMP:BHF-UCL

Interpro

InterPro; IPR002126; Cadherin
InterPro; IPR015919; Cadherin-like
InterPro; IPR020894; Cadherin_CS
InterPro; IPR000233; Cadherin_cytoplasmic-dom
InterPro; IPR027397; Catenin_binding_dom
InterPro; IPR009123; Desmoglein
InterPro; IPR009122; Desmosomal_cadherin

Pfam

Pfam; PF00028; Cadherin;
Pfam; PF01049; Cadherin_C;

SMART

SMART; SM00112; CA;

PROSITE

PROSITE; PS00232; CADHERIN_1;
PROSITE; PS50268; CADHERIN_2;

PRINTS

PRINTS; PR00205; CADHERIN;
PRINTS; PR01818; DESMOCADHERN;
PRINTS; PR01819; DESMOGLEIN;