| Tag |
Content |
LipidDB ID |
LipidDB-9606-01201 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.51 |
Molecular Weight |
86247.0 |
Genbank Protein ID |
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Genbank Nucleotide ID |
|
Protein Name |
Proprotein convertase subtilisin/kexin type 7 |
Protein Synonyms/Alias |
3.4.21.-; Lymphoma proprotein convertase; Prohormone convertase 7; Proprotein convertase 7; PC7; Proprotein convertase 8; PC8; hPC8; Subtilisin/kexin-like protease PC7; |
Gene Name |
PCSK7 |
Gene Synonyms/Alias |
LPC; PC7; PC8; SPC7; |
Created Date |
11-JAN-2001 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
699 | Canonical | NVASNQVCRSGPCHW | [1] | S-Palmitoylation | 704 | Canonical | QVCRSGPCHWPHRSR | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] van de Loo JW, Teuchert M, Pauli I, Plets E, Van de Ven WJ, Creemers JW.Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization. Biochem J. 2000 Dec15;352 Pt 3:827-33.[ PMID:11104692]
|
Functional Description |
Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. |
Sequence Annotation |
Topological domain: 142 667 Extracellular.
Transmembrane: 668 688 Helical.
Topological domain: 689 785 Cytoplasmic.
Domain: 182 474 Peptidase S8.
Active site: 187 187 Charge relay system.
Active site: 228 228 Charge relay system.
Active site: 406 406 Charge relay system.
Functional site: 141 142 Cleavage; by autolysis.
|
Protein Length |
785 AA. |
Protein Sequence
(Canonical) |
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG GPSWAVHLES 60
LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ PAGHRPALEV EAIRQQVEAV 120
LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY PQQWHLNNRR SPGRDINVTG VWERNVTGRG 180
VTVVVVDDGV EHTIQDIAPN YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP 240
NNSFCAVGVA YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP 300
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT IGAVDEEGRM 360
PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE GHTGTSAAAP LAAGMIALML 420
QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT 480
SVPYLASYVS PVLKENKAIP QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG 540
SLELKLFCPS GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF 600
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL KIPEEDGYTI 660
TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR SGPCHWPHRS RKAKEEGTEL 720
ESVPLCSSKD PDEVETESRG PPTTSDLLAP DLLEQGDWSL SQNKSALDCP HQHLDVPHGK 780
EEQIC 785
|
FASTA
(Canonical) |
>LipidDB-9606-01201|Q16549
MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
EEQIC
|
Gene Ontology |
GO:0030173; C:integral component of Golgi membrane; IDA:UniProtKB GO:0008233; F:peptidase activity; IDA:MGI GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome GO:0016486; P:peptide hormone processing; NAS:UniProtKB GO:0016485; P:protein processing; IDA:MGI |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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