LipidDB ID

LipidDB-9606-01200

Entry Name

UniProt Accession

O15162; B2R8H8; B4DTE8;

Theoretical PI

4.83

Molecular Weight

35049.07

Genbank Protein ID

AAC99413.1; BAA32568.1; AAF80593.1; BAG61960.1; BAG36175.1; EAW78926.1; AAH21100.1; AAH32718.1;

Genbank Nucleotide ID

AF098642; AB006746; AF224492; AK300181; AC069528; AC116544; AK313377; CH471052; BC021100; BC032718;

Protein Name

Phospholipid scramblase 1

Protein Synonyms/Alias

PL scramblase 1; Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b;

Gene Name

PLSCR1

Gene Synonyms/Alias

Created Date

20-JUN-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Wiedmer T, Zhao J, Nanjundan M, Sims PJ. Palmitoylation of phospholipidscramblase 1 controls its distribution between nucleus and plasma membrane.Biochemistry. 2003 Feb 11;42(5):1227-33.[PMID:12564925]

Functional Description

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

Sequence Annotation

Topological domain: 1 288 Cytoplasmic.
Transmembrane: 289 305 Helical.
Topological domain: 306 318 Extracellular.
Region: 1 84 Proline-rich domain (PRD).
Motif: 18 26 SH3-binding 1.
Motif: 22 25 WW-binding 1.
Motif: 33 36 WW-binding 2.
Motif: 42 50 SH3-binding 2.
Motif: 84 92 SH3-binding 3.
Motif: 257 266 Nuclear localization signal.
Modified residue: 69 69 Phosphotyrosine; by ABL.
Modified residue: 74 74 Phosphotyrosine; by ABL.
Modified residue: 161 161 Phosphothreonine; by PKC.

Protein Length

318 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; IDA:UniProtKB
GO:0031012; C:extracellular matrix; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; IDA:UniProtKB
GO:0005730; C:nucleolus; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005509; F:calcium ion binding; IDA:UniProtKB
GO:0042609; F:CD4 receptor binding; IPI:UniProtKB
GO:0003677; F:DNA binding; IEA:UniProtKB-KW
GO:0019899; F:enzyme binding; IPI:UniProtKB
GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB
GO:0017128; F:phospholipid scramblase activity; IDA:UniProtKB
GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB
GO:0017124; F:SH3 domain binding; IDA:UniProtKB
GO:0006953; P:acute-phase response; ISS:UniProtKB
GO:0006915; P:apoptotic process; IDA:UniProtKB
GO:0051607; P:defense response to virus; IMP:UniProtKB
GO:0045071; P:negative regulation of viral genome replication; IMP:UniProtKB
GO:0006659; P:phosphatidylserine biosynthetic process; ISS:UniProtKB
GO:0017121; P:phospholipid scrambling; IDA:UniProtKB
GO:0030168; P:platelet activation; NAS:UniProtKB
GO:2000373; P:positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; IDA:UniProtKB
GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB
GO:0045089; P:positive regulation of innate immune response; IMP:UniProtKB
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB
GO:0060368; P:regulation of Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB
GO:0033003; P:regulation of mast cell activation; ISS:UniProtKB
GO:0035456; P:response to interferon-beta; IMP:UniProtKB

Interpro

InterPro; IPR005552; Scramblase

Pfam

Pfam; PF03803; Scramblase;

SMART

PROSITE

PRINTS