LipidDB ID

LipidDB-9606-01199

Entry Name

UniProt Accession

Q96FZ7; A8K7U0; Q53FU4; Q9HAE8;

Theoretical PI

5.28

Molecular Weight

23484.83

Genbank Protein ID

AAQ91196.1; BAB13901.1; CAG33565.1; BAD96907.1; BAF84794.1; AAH10108.1;

Genbank Nucleotide ID

AY329087; AK021811; CR457284; AK223187; AK292105; BC010108;

Protein Name

Charged multivesicular body protein 6

Protein Synonyms/Alias

Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20;

Gene Name

CHMP6

Gene Synonyms/Alias

VPS20;

Created Date

30-AUG-2005

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Yorikawa C, Shibata H, Waguri S, Hatta K, Horii M, Katoh K, Kobayashi T,Uchiyama Y, Maki M. Human CHMP6, a myristoylated ESCRT-III protein, interactsdirectly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. Biochem J. 2005 Apr 1;387(Pt 1):17-26.[PMID:15511219]

Functional Description

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Sequence Annotation

Region: 170 181 Interaction with VPS4A.
Motif: 168 179 Type-2 MIT-interacting motif.

Protein Length

201 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016020; C:membrane; IDA:UniProtKB
GO:0047485; F:protein N-terminus binding; IPI:UniProtKB
GO:0016197; P:endosomal transport; TAS:Reactome
GO:0061024; P:membrane organization; TAS:Reactome
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0019058; P:viral life cycle; TAS:Reactome
GO:0016032; P:viral process; TAS:Reactome

Interpro

InterPro; IPR005024; Snf7_fam

Pfam

Pfam; PF03357; Snf7;

SMART

PROSITE

PRINTS