LipidDB ID

LipidDB-9606-01191

Entry Name

UniProt Accession

Q01453; Q8WV01;

Theoretical PI

7.75

Molecular Weight

17891.15

Genbank Protein ID

AAA36457.1; BAA01995.1; AAB26811.1; AAA58495.1; AAH19040.2; CAA46781.1;

Genbank Nucleotide ID

M94048; D11428; S61788; L03203; BC019040; X65968;

Protein Name

Peripheral myelin protein 22

Protein Synonyms/Alias

PMP-22; Growth arrest-specific protein 3; GAS-3;

Gene Name

PMP22

Gene Synonyms/Alias

GAS3;

Created Date

01-APR-1993

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Zoltewicz SJ, Lee S, Chittoor VG, Freeland SM, Rangaraju S, Zacharias DA,Notterpek L. The palmitoylation state of PMP22 modulates epithelial cellmorphology and migration. ASN Neuro. 2012 Dec 3;4(6):409-21. doi:10.1042/AN20120045.[PMID:23127255]

Functional Description

Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

Sequence Annotation

Topological domain: 1 1 Cytoplasmic.
Transmembrane: 2 31 Helical.
Topological domain: 32 64 Extracellular.
Transmembrane: 65 91 Helical.
Topological domain: 92 95 Cytoplasmic.
Transmembrane: 96 119 Helical.
Topological domain: 120 133 Extracellular.
Transmembrane: 134 156 Helical.
Topological domain: 157 160 Cytoplasmic.

Protein Length

160 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0008219; P:cell death; IEA:UniProtKB-KW
GO:0007422; P:peripheral nervous system development; TAS:ProtInc
GO:0007268; P:synaptic transmission; TAS:ProtInc

Interpro

InterPro; IPR003936; PMP22
InterPro; IPR004031; PMP22/EMP/MP20/Claudin
InterPro; IPR004032; PMP22_EMP_MP20

Pfam

Pfam; PF00822; PMP22_Claudin;

SMART

PROSITE

PROSITE; PS01221; PMP22_1;
PROSITE; PS01222; PMP22_2;

PRINTS

PRINTS; PR01453; EPMEMFAMILY;
PRINTS; PR01458; PMYELIN22;