Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01179
Entry Name
UniProt Accession
Theoretical PI
5.0
Molecular Weight
36223.35
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Transmembrane protein 59
Protein Synonyms/Alias
Liver membrane-bound protein;
Gene Name
TMEM59
Gene Synonyms/Alias
C1orf8; HSPC001; UNQ169/PRO195;
Created Date
26-SEP-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
258
Canonical
MVLLWICCATVATAV
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Sequence Annotation
Topological domain: 36 238 Extracellular.
Transmembrane: 239 259 Helical.
Topological domain: 260 323 Cytoplasmic.
Motif: 263 281 ATG16L1-binding motif.
Protein Length
323 AA.
Protein Sequence
(Canonical)
MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR ACQLTYPLHT  60
YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC TEAYSQSDEQ YACHLGCQNQ  120
LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF WSDMMDSAQS FITSSWTFYL QADDGKIVIF  180
QSKPEIQYAP HLEQEPTNLR ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW  240
ILTTTLVLSV MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR  300
SKTEDHEEAG PLPTKVNLAH SEI                                          323
FASTA
(Canonical)
>LipidDB-9606-01179|Q9BXS4
MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
QSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGW
ILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVR
SKTEDHEEAGPLPTKVNLAHSEI
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0000137; C:Golgi cis cisterna; IDA:UniProt
GO:0005797; C:Golgi medial cisterna; IDA:UniProt
GO:0000138; C:Golgi trans cisterna; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005770; C:late endosome; IDA:UniProtKB
GO:0005764; C:lysosome; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004175; F:endopeptidase activity; IEA:Ensembl
GO:0006914; P:autophagy; IEA:UniProtKB-KW
GO:0090005; P:negative regulation of establishment of protein localization to plasma membrane; IDA:UniProt
GO:0090285; P:negative regulation of protein glycosylation in Golgi; IDA:UniProt
GO:0010955; P:negative regulation of protein processing; IDA:UniProt
GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB
Interpro
InterPro; IPR022065; Uncharacterised_TMEM59
Pfam
Pfam; PF12280; BSMAP;
SMART
PROSITE
PRINTS