LipidDB-9606-01177

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-01177

Entry Name

RGS10_HUMAN

UniProt Accession

O43665; A8K408; B1AMR8; Q6IAZ6; Q96GN0;

Theoretical PI

5.35

Molecular Weight

20235.76

Genbank Protein ID

AAK52979.1; AAC03783.1; AAM12648.1; BAF83462.1; CAG33289.1; CAI16486.1; CAI16486.1; CAI16488.1; EAW49389.1; EAW49390.1; AAH09361.1;

Genbank Nucleotide ID

AF368902; AF045229; AF493934; AK290773; CR457008; AL355273; AC012468; AL355273; CH471066; CH471066; BC009361;

Protein Name

Regulator of G-protein signaling 10

Protein Synonyms/Alias

RGS10;

Gene Name

RGS10

Gene Synonyms/Alias

Created Date

15-DEC-1998

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
66	Canonical	NVLFWLACEDFKKMQ	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Castro-Fernández C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM.Regulation of RGS3 and RGS10 palmitoylation by GnRH. Endocrinology. 2002Apr;143(4):1310-7.[PMID:11897687]

Functional Description

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

Sequence Annotation

Domain: 33 148 RGS.

Protein Length

173 AA.

Protein Sequence
(Canonical)

MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF LKKEFSEENV  60
LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV EGQSRLNEKI LEEPHPLMFQ  120
KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT EEEEEDLPDA QTAAKRASRI YNT         173

FASTA
(Canonical)

>LipidDB-9606-01177|O43665
MQSELCFADIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENV
LFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQ
KLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT

Gene Ontology

GO:0043679; C:axon terminus; IEA:Ensembl
GO:0005737; C:cytoplasm; IBA:RefGenome
GO:0043197; C:dendritic spine; IEA:Ensembl
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005634; C:nucleus; IDA:HPA
GO:0005886; C:plasma membrane; IBA:RefGenome
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0043547; P:positive regulation of GTPase activity; IBA:GOC
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro

Interpro

InterPro; IPR024066; Regulat_G_prot_signal_dom1
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom

Pfam

Pfam; PF00615; RGS;

SMART

SMART; SM00315; RGS;

PROSITE

PROSITE; PS50132; RGS;

PRINTS

PRINTS; PR01301; RGSPROTEIN;