LipidDB ID

LipidDB-9606-01174

Entry Name

UniProt Accession

P00441; A6NHJ0; D3DSE4; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85;

Theoretical PI

5.7

Molecular Weight

15935.74

Genbank Protein ID

AAB05662.1; AAB05662.1; AAB05662.1; AAB05662.1; AAB05661.1; AAB05661.1; AAB05661.1; AAB05661.1; CAA26182.1; CAA25915.1; CAA25916.1; CAA25917.1; CAA25918.1; CAA25919.1; AAL15444.1; AAR21563.1; ABL96616.1; BAG35052.1; CAG29351.1; CAG46542.1; AAP35322.1; AAV80422.1; EAX09889.1; EAX09890.1; AAH01034.1; AAB59626.1; AAB59627.1; AAC41773.1; CAA64520.1;

Genbank Nucleotide ID

L44139; L44135; L44136; L44137; L44139; L44135; L44136; L44137; X02317; X01780; X01781; X01782; X01783; X01784; AY049787; AY450286; EF151142; AK312116; CR450355; CR541742; BT006676; AY835629; AP000253; CH471079; CH471079; BC001034; L46374; L46375; L44746; X95228;

Protein Name

Superoxide dismutase [Cu-Zn]

Protein Synonyms/Alias

1.15.1.1; Superoxide dismutase 1; hSod1;

Gene Name

SOD1

Gene Synonyms/Alias

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation ofsuperoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateralsclerosis-linked SOD1 mutants. J Biol Chem. 2013 Jul 26;288(30):21606-17. doi:10.1074/jbc.M113.487231. Epub 2013 Jun 12.[PMID:23760509]

Functional Description

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Sequence Annotation

Metal binding site: 47 47 Copper; catalytic.
Metal binding site: 49 49 Copper; catalytic.
Metal binding site: 64 64 Copper; catalytic.
Metal binding site: 64 64 Zinc; via pros nitrogen.
Metal binding site: 72 72 Zinc; via pros nitrogen.
Metal binding site: 81 81 Zinc; via pros nitrogen.
Metal binding site: 84 84 Zinc; structural.
Metal binding site: 121 121 Copper; catalytic.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 4 4 N6-succinyllysine.
Modified residue: 10 10 N6-succinyllysine.
Modified residue: 92 92 N6-succinyllysine.
Modified residue: 99 99 Phosphoserine.
Modified residue: 123 123 N6-acetyllysine; alternate.
Modified residue: 123 123 N6-succinyllysine; alternate.
Modified residue: 137 137 N6-acetyllysine; alternate.
Modified residue: 137 137 N6-succinyllysine; alternate.

Protein Length

154 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0032839; C:dendrite cytoplasm; IDA:UniProtKB
GO:0031012; C:extracellular matrix; IDA:UniProtKB
GO:0005576; C:extracellular region; TAS:Reactome
GO:0005615; C:extracellular space; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome
GO:0005759; C:mitochondrial matrix; NAS:UniProtKB
GO:0005739; C:mitochondrion; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005777; C:peroxisome; IDA:UniProtKB
GO:0043234; C:protein complex; IDA:UniProtKB
GO:0051087; F:chaperone binding; IPI:UniProtKB
GO:0005507; F:copper ion binding; IDA:UniProtKB
GO:0042802; F:identical protein binding; IPI:IntAct
GO:0042803; F:protein homodimerization activity; NAS:UniProtKB
GO:0030346; F:protein phosphatase 2B binding; IDA:UniProtKB
GO:0048365; F:Rac GTPase binding; IDA:UniProtKB
GO:0004784; F:superoxide dismutase activity; IDA:UniProtKB
GO:0008270; F:zinc ion binding; IDA:UniProtKB
GO:0000187; P:activation of MAPK activity; ISS:UniProtKB
GO:0008089; P:anterograde axon cargo transport; ISS:BHF-UCL
GO:0060088; P:auditory receptor cell stereocilium organization; ISS:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007569; P:cell aging; IMP:UniProtKB
GO:0008219; P:cell death; IEA:UniProtKB-KW
GO:0006879; P:cellular iron ion homeostasis; ISS:UniProtKB
GO:0007566; P:embryo implantation; ISS:UniProtKB
GO:0006749; P:glutathione metabolic process; ISS:UniProtKB
GO:0060047; P:heart contraction; IDA:UniProtKB
GO:0050665; P:hydrogen peroxide biosynthetic process; IDA:UniProtKB
GO:0007626; P:locomotory behavior; ISS:UniProtKB
GO:0046716; P:muscle cell cellular homeostasis; ISS:UniProtKB
GO:0002262; P:myeloid cell homeostasis; ISS:UniProtKB
GO:0045541; P:negative regulation of cholesterol biosynthetic process; IDA:UniProtKB
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB
GO:0060052; P:neurofilament cytoskeleton organization; ISS:UniProtKB
GO:0001541; P:ovarian follicle development; ISS:UniProtKB
GO:0032287; P:peripheral nervous system myelin maintenance; ISS:UniProtKB
GO:0001890; P:placenta development; NAS:UniProtKB
GO:0030168; P:platelet activation; TAS:Reactome
GO:0002576; P:platelet degranulation; TAS:Reactome
GO:0043065; P:positive regulation of apoptotic process; IC:UniProtKB
GO:0043085; P:positive regulation of catalytic activity; IDA:UniProtKB
GO:0001819; P:positive regulation of cytokine production; IDA:UniProtKB
GO:1902177; P:positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IMP:BHF-UCL
GO:0032930; P:positive regulation of superoxide anion generation; IDA:UniProtKB
GO:0072593; P:reactive oxygen species metabolic process; IDA:UniProtKB
GO:0008217; P:regulation of blood pressure; ISS:UniProtKB
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB
GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB
GO:0046620; P:regulation of organ growth; NAS:UniProtKB
GO:0045859; P:regulation of protein kinase activity; IDA:UniProtKB
GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB
GO:0033081; P:regulation of T cell differentiation in thymus; NAS:UniProtKB
GO:0060087; P:relaxation of vascular smooth muscle; ISS:UniProtKB
GO:0019430; P:removal of superoxide radicals; ISS:UniProtKB
GO:0001975; P:response to amphetamine; IEA:Ensembl
GO:0048678; P:response to axon injury; ISS:UniProtKB
GO:0046688; P:response to copper ion; IEA:Ensembl
GO:0042493; P:response to drug; ISS:UniProtKB
GO:0045471; P:response to ethanol; ISS:UniProtKB
GO:0009408; P:response to heat; ISS:UniProtKB
GO:0042542; P:response to hydrogen peroxide; ISS:UniProtKB
GO:0031667; P:response to nutrient levels; IEA:Ensembl
GO:0010033; P:response to organic substance; IDA:UniProtKB
GO:0000303; P:response to superoxide; IDA:UniProtKB
GO:0001895; P:retina homeostasis; ISS:UniProtKB
GO:0008090; P:retrograde axon cargo transport; ISS:BHF-UCL
GO:0007605; P:sensory perception of sound; ISS:UniProtKB
GO:0007283; P:spermatogenesis; ISS:UniProtKB
GO:0042554; P:superoxide anion generation; IEA:Ensembl
GO:0006801; P:superoxide metabolic process; ISS:UniProtKB
GO:0048538; P:thymus development; NAS:UniProtKB
GO:0019226; P:transmission of nerve impulse; ISS:UniProtKB

Interpro

InterPro; IPR018152; SOD_Cu/Zn_BS
InterPro; IPR001424; SOD_Cu_Zn_dom

Pfam

Pfam; PF00080; Sod_Cu;

SMART

PROSITE

PROSITE; PS00087; SOD_CU_ZN_1;
PROSITE; PS00332; SOD_CU_ZN_2;

PRINTS

PRINTS; PR00068; CUZNDISMTASE;