LipidDB ID

LipidDB-9606-01164

Entry Name

UniProt Accession

P51809; Q53GY7; Q7Z409; Q9H4A7;

Theoretical PI

8.86

Molecular Weight

24935.06

Genbank Protein ID

CAA63133.1; CAB96816.1; CAD70593.2; CAC16891.1; BAD96514.1; AAH56141.1;

Genbank Nucleotide ID

X92396; AJ271736; AJ549301; AJ295938; AK222794; BC056141; BI547528;

Protein Name

Vesicle-associated membrane protein 7

Protein Synonyms/Alias

VAMP-7; Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; Ti-VAMP;

Gene Name

VAMP7

Gene Synonyms/Alias

SYBL1;

Created Date

01-OCT-1996

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Sequence Annotation

Topological domain: 2 188 Cytoplasmic.
Transmembrane: 189 209 Helical; Anchor for type IV membraneprotein.
Topological domain: 210 220 Vesicular.
Domain: 7 110 Longin.
Domain: 125 185 v-SNARE coiled-coil homology.
Modified residue: 2 2 N-acetylalanine; partial.
Modified residue: 168 168 Phosphoserine.

Protein Length

220 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0045177; C:apical part of cell; IEA:Ensembl
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0009986; C:cell surface; IEA:Ensembl
GO:0005737; C:cytoplasm; IDA:HPA
GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:HPA
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA
GO:0031902; C:late endosome membrane; ISS:UniProtKB
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0043005; C:neuron projection; ISS:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0045335; C:phagocytic vesicle; ISS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031201; C:SNARE complex; ISS:UniProtKB
GO:0045202; C:synapse; IEA:UniProtKB-KW
GO:0017156; P:calcium ion-dependent exocytosis; ISS:UniProtKB
GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB
GO:0043308; P:eosinophil degranulation; ISS:UniProtKB
GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB
GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Ensembl
GO:0061024; P:membrane organization; TAS:Reactome
GO:0043312; P:neutrophil degranulation; ISS:UniProtKB
GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB
GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome
GO:1900483; P:regulation of protein targeting to vacuolar membrane; IEA:Ensembl
GO:0035493; P:SNARE complex assembly; IEA:Ensembl
GO:0034197; P:triglyceride transport; IEA:Ensembl
GO:0006906; P:vesicle fusion; IDA:UniProtKB
GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:Ensembl
GO:0016192; P:vesicle-mediated transport; IDA:UniProtKB

Interpro

InterPro; IPR011012; Longin-like_dom
InterPro; IPR010908; Longin_dom
InterPro; IPR001388; Synaptobrevin

Pfam

Pfam; PF13774; Longin;
Pfam; PF00957; Synaptobrevin;

SMART

PROSITE

PROSITE; PS50859; LONGIN;
PROSITE; PS00417; SYNAPTOBREVIN;
PROSITE; PS50892; V_SNARE;

PRINTS

PRINTS; PR00219; SYNAPTOBREVN;