LipidDB ID

LipidDB-9606-01161

Entry Name

UniProt Accession

P59768; Q5JPE2; Q6P9A9;

Theoretical PI

7.78

Molecular Weight

7850.14

Genbank Protein ID

AAM12584.1; CAI46198.1; EAW65663.1; AAH20774.1; AAH60856.1;

Genbank Nucleotide ID

AF493870; AL832878; CH471078; BC020774; BC060856;

Protein Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Protein Synonyms/Alias

G gamma-I;

Gene Name

GNG2

Gene Synonyms/Alias

Created Date

11-JUL-2003

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Takida S, Wedegaertner PB. Heterotrimer formation, together withisoprenylation, is required for plasma membrane targeting of Gbetagamma. J BiolChem. 2003 May 9;278(19):17284-90. Epub 2003 Feb 27.[PMID:12609996]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity).

Sequence Annotation

Modified residue: 2 2 N-acetylalanine.
Modified residue: 68 68 Cysteine methyl ester.

Protein Length

71 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005834; C:heterotrimeric G-protein complex; ISS:BHF-UCL
GO:0016020; C:membrane; ISS:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031681; F:G-protein beta-subunit binding; IPI:UniProt
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISS:BHF-UCL
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0071870; P:cellular response to catecholamine stimulus; ISS:BHF-UCL
GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome
GO:0071380; P:cellular response to prostaglandin E stimulus; ISS:BHF-UCL
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0030168; P:platelet activation; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0007268; P:synaptic transmission; TAS:Reactome

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS

PRINTS; PR00321; GPROTEING;