Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01156
Entry Name
UniProt Accession
Theoretical PI
6.64
Molecular Weight
33067.52
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Tissue factor
Protein Synonyms/Alias
TF; Coagulation factor III; Thromboplastin; CD142;
Gene Name
F3
Gene Synonyms/Alias
Created Date
01-JAN-1990
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
277
Canonical
LAISLHKCRKAGVGQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Dorfleutner A, Ruf W. Regulation of tissue factor cytoplasmic domainphosphorylation by palmitoylation. Blood. 2003 Dec 1;102(12):3998-4005. Epub 2003Aug 14.[PMID:12920028]
Functional Description
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Sequence Annotation
Topological domain: 33 251 Extracellular.
Transmembrane: 252 274 Helical.
Topological domain: 275 295 Cytoplasmic.
Motif: 46 48 WKS motif.
Motif: 77 79 WKS motif.
Motif: 190 192 WKS motif.
Protein Length
295 AA.
Protein Sequence
(Canonical)
METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK  60
PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS  120
AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG  180
KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE  240
CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS       295
FASTA
(Canonical)
>LipidDB-9606-01156|P13726
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
Gene Ontology
GO:0009986; C:cell surface; IDA:UniProtKB
GO:0031012; C:extracellular matrix; IDA:BHF-UCL
GO:0005615; C:extracellular space; IDA:BHF-UCL
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; TAS:ProtInc
GO:0031233; C:intrinsic component of external side of plasma membrane; IC:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005543; F:phospholipid binding; IDA:BHF-UCL
GO:0002020; F:protease binding; IPI:BHF-UCL
GO:0002543; P:activation of blood coagulation via clotting cascade; IC:BHF-UCL
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL
GO:0002541; P:activation of plasma proteins involved in acute inflammatory response; IDA:BHF-UCL
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007598; P:blood coagulation, extrinsic pathway; TAS:Reactome
GO:0045766; P:positive regulation of angiogenesis; IDA:BHF-UCL
GO:0030335; P:positive regulation of cell migration; TAS:BHF-UCL
GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL
GO:0010641; P:positive regulation of platelet-derived growth factor receptor signaling pathway; IDA:BHF-UCL
GO:0050927; P:positive regulation of positive chemotaxis; IC:BHF-UCL
GO:0051897; P:positive regulation of protein kinase B signaling; IMP:BHF-UCL
Interpro
InterPro; IPR003961; Fibronectin_type3
InterPro; IPR013783; Ig-like_fold
InterPro; IPR015373; Interferon_alpha/beta_rcpt_bsu
InterPro; IPR016354; Tissue_fac/coagulation_fac-3
InterPro; IPR001187; Tissue_factor
Pfam
Pfam; PF09294; Interfer-bind;
Pfam; PF01108; Tissue_fac;
SMART
PROSITE
PROSITE; PS00621; TISSUE_FACTOR;
PRINTS
PRINTS; PR00346; TISSUEFACTOR;