Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01150
Entry Name
UniProt Accession
Theoretical PI
8.12
Molecular Weight
44049.58
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Guanine nucleotide-binding protein subunit alpha-13
Protein Synonyms/Alias
G alpha-13; G-protein subunit alpha-13;
Gene Name
GNA13
Gene Synonyms/Alias
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
14
Canonical
SRSVLSVCFPGCLLT
[1]
S-Palmitoylation
18
Canonical
LSVCFPGCLLTSGEA
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Bhattacharyya R, Wedegaertner PB. Galpha 13 requires palmitoylation for plasmamembrane localization, Rho-dependent signaling, and promotion of p115-RhoGEFmembrane binding. J Biol Chem. 2000 May 19;275(20):14992-9.[PMID:10747909]
Functional Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence Annotation
Nucleotide-binding: 55 62 GTP.
Nucleotide-binding: 197 203 GTP.
Nucleotide-binding: 222 226 GTP.
Nucleotide-binding: 291 294 GTP.
Metal binding site: 62 62 Magnesium.
Metal binding site: 203 203 Magnesium.
Binding site: 349 349 GTP; via amide nitrogen.
Modified residue: 203 203 Phosphothreonine; by PKA.
Protein Length
377 AA.
Protein Sequence
(Canonical)
MADFLPSRSV LSVCFPGCLL TSGEAEQQRK SKEIDKCLSR EKTYVKRLVK ILLLGAGESG  60
KSTFLKQMRI IHGQDFDQRA REEFRPTIYS NVIKGMRVLV DAREKLHIPW GDNSNQQHGD  120
KMMSFDTRAP MAAQGMVETR VFLQYLPAIR ALWADSGIQN AYDRRREFQL GESVKYFLDN  180
LDKLGEPDYI PSQQDILLAR RPTKGIHEYD FEIKNVPFKM VDVGGQRSER KRWFECFDSV  240
TSILFLVSSS EFDQVLMEDR LTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV  300
QIVSIKDYFL EFEGDPHCLR DVQKFLVECF RNKRRDQQQK PLYHHFTTAI NTENIRLVFR  360
DVKDTILHDN LKQLMLQ                                                 377
FASTA
(Canonical)
>LipidDB-9606-01150|Q14344
MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESG
KSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNSNQQHGD
KMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLGESVKYFLDN
LDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSV
TSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKV
QIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFR
DVKDTILHDNLKQLMLQ
Gene Ontology
GO:0031526; C:brush border membrane; IBA:RefGenome
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031752; F:D5 dopamine receptor binding; IBA:RefGenome
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0031702; F:type 1 angiotensin receptor binding; IBA:RefGenome
GO:0031584; P:activation of phospholipase D activity; IBA:RefGenome
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IBA:RefGenome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0030154; P:cell differentiation; IEA:Ensembl
GO:0006928; P:cellular component movement; TAS:ProtInc
GO:0001701; P:in utero embryonic development; IEA:Ensembl
GO:0001569; P:patterning of blood vessels; IEA:Ensembl
GO:0030168; P:platelet activation; TAS:Reactome
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl
GO:0030334; P:regulation of cell migration; IEA:Ensembl
GO:0008360; P:regulation of cell shape; IEA:Ensembl
GO:0007266; P:Rho protein signal transduction; IBA:RefGenome
GO:0007165; P:signal transduction; TAS:ProtInc
Interpro
InterPro; IPR000469; Gprotein_alpha_12
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00503; G-alpha;
SMART
SMART; SM00275; G_alpha;
PROSITE
PRINTS
PRINTS; PR00318; GPROTEINA;
PRINTS; PR00440; GPROTEINA12;