Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01149
Entry Name
UniProt Accession
Theoretical PI
6.32
Molecular Weight
158456.55
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Netrin receptor DCC
Protein Synonyms/Alias
Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC;
Gene Name
DCC
Gene Synonyms/Alias
IGDCC1;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
1121
Canonical
VVIVAVICTRRSSAQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hérincs Z, Corset V, Cahuzac N, Furne C, Castellani V, Hueber AO, Mehlen P.DCC association with lipid rafts is required for netrin-1-mediated axon guidance.J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92.[PMID:15811950]
Functional Description
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Sequence Annotation
Topological domain: 26 1097 Extracellular.
Transmembrane: 1098 1122 Helical.
Topological domain: 1123 1447 Cytoplasmic.
Domain: 26 135 Ig-like C2-type 1.
Domain: 139 229 Ig-like C2-type 2.
Domain: 234 326 Ig-like C2-type 3.
Domain: 331 416 Ig-like C2-type 4.
Domain: 431 524 Fibronectin type-III 1.
Domain: 530 620 Fibronectin type-III 2.
Domain: 625 718 Fibronectin type-III 3.
Domain: 728 821 Fibronectin type-III 4.
Domain: 846 942 Fibronectin type-III 5.
Domain: 947 1044 Fibronectin type-III 6.
Region: 1432 1439 Interaction with MYO10.
Modified residue: 1178 1178 Phosphoserine; by MAPK1.
Modified residue: 1187 1187 Phosphothreonine; by MAPK1.
Modified residue: 1267 1267 Phosphoserine; by MAPK1.
Protein Length
1447 AA.
Protein Sequence
(Canonical)
MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV TMRGGNVLLD  60
CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ NILHSRHHKP DEGLYQCEAS  120
LGDSGSIISR TAKVAVAGPL RFLSQTESVT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL  180
TPIPGDSRVV VLPSGALQIS RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL  240
YFLQRPSNVV AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV  300
TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECTVSGKPVP  360
TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ TSAQLIVPKP  420
AIPSSSVLPS APRDVVPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT  480
QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS  540
PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA  600
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI  660
RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL  720
DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY  780
YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL  840
STPMLPPVGV QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT  900
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD LTVITREGKP  960
RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLNLDTMYYF  1020
RIQARNSKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI  1080
GQMHPPHGSV TPQKNSNLLV IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK  1140
RKGSQKDLRP PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS  1200
KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA IPVPTLESAQ  1260
YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS VSEGPTTQQP PMLPPSQPEH  1320
SSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK  1380
TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN  1440
AITGSAF                                                            1447
FASTA
(Canonical)
>LipidDB-9606-01149|P43146
MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD
CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS
LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL
TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL
YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV
TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP
TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP
AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT
QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS
PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA
YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI
RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL
DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY
YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL
STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT
TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP
RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF
RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI
GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK
RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS
KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ
YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH
SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK
TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN
AITGSAF
Gene Ontology
GO:0030424; C:axon; IEA:Ensembl
GO:0005829; C:cytosol; TAS:Reactome
GO:0032584; C:growth cone membrane; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005042; F:netrin receptor activity; IEA:Ensembl
GO:0003713; F:transcription coactivator activity; IEA:Ensembl
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc
GO:0033564; P:anterior/posterior axon guidance; IEA:Ensembl
GO:0006915; P:apoptotic process; TAS:Reactome
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007409; P:axonogenesis; TAS:ProtInc
GO:0033563; P:dorsal/ventral axon guidance; IEA:Ensembl
GO:0048671; P:negative regulation of collateral sprouting; TAS:BHF-UCL
GO:2000171; P:negative regulation of dendrite development; TAS:BHF-UCL
GO:0010977; P:negative regulation of neuron projection development; TAS:BHF-UCL
GO:0001764; P:neuron migration; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl
GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl
GO:0042981; P:regulation of apoptotic process; TAS:Reactome
GO:0001975; P:response to amphetamine; IEA:Ensembl
GO:0021965; P:spinal cord ventral commissure morphogenesis; IEA:Ensembl
Interpro
InterPro; IPR003961; Fibronectin_type3
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR013098; Ig_I-set
InterPro; IPR003599; Ig_sub
InterPro; IPR003598; Ig_sub2
InterPro; IPR010560; Neogenin_C
Pfam
Pfam; PF00041; fn3;
Pfam; PF07679; I-set;
Pfam; PF06583; Neogenin_C;
SMART
SMART; SM00060; FN3;
SMART; SM00409; IG;
SMART; SM00408; IGc2;
PROSITE
PROSITE; PS50853; FN3;
PROSITE; PS50835; IG_LIKE;
PRINTS