LipidDB ID

LipidDB-9606-01137

Entry Name

UniProt Accession

O43687; A8K2K6; Q5TBR9; Q5TBS0; Q9HCZ8; Q9P0G4;

Theoretical PI

4.89

Molecular Weight

11464.52

Genbank Protein ID

AAC39715.1; AAF26676.1; BAF82960.1; CAI21507.1; CAI21507.1; CAI21508.1; CAI21508.1; CAI19001.1; CAI19001.1; CAI19002.1; CAI19002.1; EAW48057.1; AAH16927.1; AAH73847.1; AAH94732.1;

Genbank Nucleotide ID

AF047715; AF161075; AK290271; AL136110; AL137063; AL136110; AL137063; AL137063; AL136110; AL137063; AL136110; CH471051; BC016927; BC073847; BC094732;

Protein Name

A-kinase anchor protein 7 isoforms alpha and beta

Protein Synonyms/Alias

AKAP-7 isoforms alpha and beta; A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta;

Gene Name

AKAP7

Gene Synonyms/Alias

AKAP15; AKAP18;

Created Date

30-MAY-2000

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD. A novel lipid-anchored A-kinase Anchoring Protein facilitatescAMP-responsive membrane events. EMBO J. 1998 Apr 15;17(8):2261-72.[PMID:9545239]

Functional Description

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Sequence Annotation

Region: 2 11 Required for membrane localization.
Region: 18 40 Required for apical membranelocalization.
Region: 52 65 RII-binding.

Protein Length

104 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IDA:UniProtKB
GO:0016328; C:lateral plasma membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:UniProtKB
GO:0051018; F:protein kinase A binding; IDA:UniProtKB
GO:0001508; P:action potential; IC:BHF-UCL
GO:0071320; P:cellular response to cAMP; IDA:BHF-UCL
GO:0035556; P:intracellular signal transduction; TAS:UniProtKB
GO:0006811; P:ion transport; TAS:ProtInc
GO:1902261; P:positive regulation of delayed rectifier potassium channel activity; IDA:BHF-UCL
GO:1901381; P:positive regulation of potassium ion transmembrane transport; IDA:BHF-UCL
GO:0008104; P:protein localization; IC:UniProtKB
GO:0060306; P:regulation of membrane repolarization; IDA:BHF-UCL

Interpro

InterPro; IPR019511; Kinase-A_anchor_RI-RII-bd_dom

Pfam

Pfam; PF10470; AKAP7_RIRII_bdg;

SMART

PROSITE

PRINTS