| Tag |
Content |
LipidDB ID |
LipidDB-9606-01132 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.39 |
Molecular Weight |
40251.11 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Retinoic acid-induced protein 3 |
Protein Synonyms/Alias |
G-protein coupled receptor family C group 5 member A; Orphan G-protein-coupling receptor PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1; |
Gene Name |
GPRC5A |
Gene Synonyms/Alias |
GPCR5A; RAI3; RAIG1; |
Created Date |
13-APR-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
9 | Canonical | ATTVPDGCRNGLKSK | [1] | S-Palmitoylation | 54 | Canonical | LTLPILVCKVQDSNR | [1] | S-Palmitoylation | 200 | Canonical | LMSSFTFCGSFTGWK | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. |
Sequence Annotation |
Topological domain: 1 33 Extracellular.
Transmembrane: 34 54 Helical; Name=1.
Topological domain: 55 68 Cytoplasmic.
Transmembrane: 69 89 Helical; Name=2.
Topological domain: 90 97 Extracellular.
Transmembrane: 98 118 Helical; Name=3.
Topological domain: 119 129 Cytoplasmic.
Transmembrane: 130 150 Helical; Name=4.
Topological domain: 151 176 Extracellular.
Transmembrane: 177 197 Helical; Name=5.
Topological domain: 198 212 Cytoplasmic.
Transmembrane: 213 233 Helical; Name=6.
Topological domain: 234 247 Extracellular.
Transmembrane: 248 268 Helical; Name=7.
Topological domain: 269 357 Cytoplasmic.
Modified residue: 301 301 Phosphoserine.
Modified residue: 345 345 Phosphoserine.
Modified residue: 350 350 Phosphotyrosine.
|
Protein Length |
357 AA. |
Protein Sequence
(Canonical) |
MATTVPDGCR NGLKSKYYRL CDKAEAWGIV LETVATAGVV TSVAFMLTLP ILVCKVQDSN 60
RRKMLPTQFL FLLGVLGIFG LTFAFIIGLD GSTGPTRFFL FGILFSICFS CLLAHAVSLT 120
KLVRGRKPLS LLVILGLAVG FSLVQDVIAI EYIVLTMNRT NVNVFSELSA PRRNEDFVLL 180
LTYVLFLMAL TFLMSSFTFC GSFTGWKRHG AHIYLTMLLS IAIWVAWITL LMLPDFDRRW 240
DDTILSSALA ANGWVFLLAY VSPEFWLLTK QRNPMDYPVE DAFCKPQLVK KSYGVENRAY 300
SQEEITQGFE ETGDTLYAPY STHFQLQNQP PQKEFSIPRA HAWPSPYKDY EVKKEGS 357
|
FASTA
(Canonical) |
>LipidDB-9606-01132|Q8NFJ5
MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSN
RRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLT
KLVRGRKPLSLLVILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSELSAPRRNEDFVLL
LTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRW
DDTILSSALAANGWVFLLAYVSPEFWLLTKQRNPMDYPVEDAFCKPQLVKKSYGVENRAY
SQEEITQGFEETGDTLYAPYSTHFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS
|
Gene Ontology |
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB GO:0005887; C:integral component of plasma membrane; TAS:ProtInc GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO:0005886; C:plasma membrane; IDA:HPA GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc GO:0007165; P:signal transduction; TAS:ProtInc |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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