LipidDB ID

LipidDB-9606-01116

Entry Name

UniProt Accession

Q658P3; A8K6E3; Q4VBR2; Q4ZG36; Q53SQ8; Q7Z389; Q86SF6; Q8NEW6; Q8TDP3; Q8TF03; Q9NVB5;

Theoretical PI

8.86

Molecular Weight

54600.64

Genbank Protein ID

AAO38238.1; AAQ04065.1; AAL78206.1; AAM08128.1; AAK50538.1; AAM45136.1; BAA91839.1; BAF84297.1; CAH56204.1; CAD97986.1; AAX88963.1; AAY14872.1; EAW95209.1; AAH42150.1; AAH95421.2;

Genbank Nucleotide ID

AY214461; AF423424; AF238864; AF262322; AY029585; AY082673; AK001691; AK291608; AL833624; BX538047; AC016673; AC016736; CH471103; BC042150; BC095421;

Protein Name

Metalloreductase STEAP3

Protein Synonyms/Alias

1.16.1.-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde;

Gene Name

STEAP3

Gene Synonyms/Alias

TSAP6;

Created Date

01-MAY-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Sequence Annotation

Topological domain: 1 207 Cytoplasmic.
Transmembrane: 208 228 Helical.
Topological domain: 229 258 Vesicular.
Transmembrane: 259 279 Helical.
Topological domain: 280 304 Cytoplasmic.
Transmembrane: 305 325 Helical.
Topological domain: 326 358 Vesicular.
Transmembrane: 359 379 Helical.
Topological domain: 380 390 Cytoplasmic.
Transmembrane: 391 411 Helical.
Topological domain: 412 433 Vesicular.
Transmembrane: 434 454 Helical.
Topological domain: 455 488 Cytoplasmic.
Domain: 259 407 Ferric oxidoreductase.
Metal binding site: 316 316 Iron (heme axial ligand).
Metal binding site: 409 409 Iron (heme axial ligand).
Binding site: 36 36 NADP.
Binding site: 38 38 NADP; via amide nitrogen.
Binding site: 39 39 NADP; via amide nitrogen.
Binding site: 58 58 NADP.
Binding site: 59 59 NADP.
Binding site: 91 91 NADP; via carbonyl oxygen.
Binding site: 116 116 NADP; via amide nitrogen.
Binding site: 151 151 NADP; via amide nitrogen.
Functional site: 325 326 Cleavage; by RHBDL4/RHBDD1.
Modified residue: 17 17 Phosphoserine.
Modified residue: 20 20 Phosphoserine.

Protein Length

488 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0010008; C:endosome membrane; TAS:Reactome
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005771; C:multivesicular body; IDA:MGI
GO:0005886; C:plasma membrane; IEA:Ensembl
GO:0008823; F:cupric reductase activity; IEA:Ensembl
GO:0052851; F:ferric-chelate reductase (NADPH) activity; IEA:Ensembl
GO:0000293; F:ferric-chelate reductase activity; IEA:Ensembl
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome
GO:0015677; P:copper ion import; IEA:Ensembl
GO:1990182; P:exosomal secretion; IEA:Ensembl
GO:0097461; P:ferric iron import into cell; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl
GO:1902167; P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl
GO:0009306; P:protein secretion; IMP:UniProtKB
GO:0033572; P:transferrin transport; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR013130; Fe3_Rdtase_TM_dom
InterPro; IPR016040; NAD(P)-bd_dom
InterPro; IPR028939; ProC_N

Pfam

Pfam; PF03807; F420_oxidored;
Pfam; PF01794; Ferric_reduct;

SMART

PROSITE

PRINTS