Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01115
Entry Name
UniProt Accession
Theoretical PI
8.67
Molecular Weight
87432.16
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
cGMP-dependent protein kinase 2
Protein Synonyms/Alias
cGK 2; cGK2; 2.7.11.12; cGMP-dependent protein kinase II; cGKII;
Gene Name
PRKG2
Gene Synonyms/Alias
PRKGR2;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGNGSVKPK
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Vaandrager AB, Ehlert EM, Jarchau T, Lohmann SM, de Jonge HR. N-terminalmyristoylation is required for membrane localization of cGMP-dependent proteinkinase type II. J Biol Chem. 1996 Mar 22;271(12):7025-9.[PMID:8636133]
Functional Description
Sequence Annotation
Domain: 453 711 Protein kinase.
Domain: 712 762 AGC-kinase C-terminal.
Nucleotide-binding: 168 285 cGMP 1.
Nucleotide-binding: 286 417 cGMP 2.
Nucleotide-binding: 459 467 ATP.
Active site: 576 576 Proton acceptor.
Binding site: 482 482 ATP.
Protein Length
762 AA.
Protein Sequence
(Canonical)
MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH LKELREQLSK  60
QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG  120
AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM  180
VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC  240
TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID  300
CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL  360
ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS  420
MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA  480
MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS  540
ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK  600
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGVDQMMTYN  660
LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK  720
ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM PPDELSGWDK DF                     762
FASTA
(Canonical)
>LipidDB-9606-01115|Q13237
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK
QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG
AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM
VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC
TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID
CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL
ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS
MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA
MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS
ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK
IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN
LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK
ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0030553; F:cGMP binding; IEA:UniProtKB-KW
GO:0004692; F:cGMP-dependent protein kinase activity; IEA:UniProtKB-EC
GO:0004672; F:protein kinase activity; TAS:ProtInc
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl
GO:0046209; P:nitric oxide metabolic process; TAS:Reactome
GO:0006468; P:protein phosphorylation; TAS:ProtInc
GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0044281; P:small molecule metabolic process; TAS:Reactome
Interpro
InterPro; IPR000961; AGC-kinase_C
InterPro; IPR016232; cGMP-dependent_protein_kinase
InterPro; IPR002374; cGMP_dep_kinase
InterPro; IPR018490; cNMP-bd-like
InterPro; IPR018488; cNMP-bd_CS
InterPro; IPR000595; cNMP-bd_dom
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR014710; RmlC-like_jellyroll
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS
Pfam
Pfam; PF00027; cNMP_binding;
Pfam; PF00069; Pkinase;
SMART
SMART; SM00100; cNMP;
SMART; SM00133; S_TK_X;
SMART; SM00220; S_TKc;
PROSITE
PROSITE; PS51285; AGC_KINASE_CTER;
PROSITE; PS00888; CNMP_BINDING_1;
PROSITE; PS00889; CNMP_BINDING_2;
PROSITE; PS50042; CNMP_BINDING_3;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;
PRINTS
PRINTS; PR00104; CGMPKINASE;