Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01111
Entry Name
UniProt Accession
Theoretical PI
8.62
Molecular Weight
47440.51
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Proteinase-activated receptor 1
Protein Synonyms/Alias
PAR-1; Coagulation factor II receptor; Thrombin receptor;
Gene Name
F2R
Gene Synonyms/Alias
CF2R; PAR1; TR;
Created Date
01-MAY-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
387
Canonical
RYVYSILCCKESSDP
[1]
S-Palmitoylation
388
Canonical
YVYSILCCKESSDPS
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Dowal L, Sim DS, Dilks JR, Blair P, Beaudry S, Denker BM, Koukos G, KuliopulosA, Flaumenhaft R. Identification of an antithrombotic allosteric modulator thatacts through helix 8 of PAR1. Proc Natl Acad Sci U S A. 2011 Feb15;108(7):2951-6. doi: 10.1073/pnas.1014863108. Epub 2011 Jan 31.[PMID:21282664]
Functional Description
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Sequence Annotation
Topological domain: 42 102 Extracellular.
Transmembrane: 103 128 Helical; Name=1.
Topological domain: 129 137 Cytoplasmic.
Transmembrane: 138 157 Helical; Name=2.
Topological domain: 158 176 Extracellular.
Transmembrane: 177 198 Helical; Name=3.
Topological domain: 199 218 Cytoplasmic.
Transmembrane: 219 239 Helical; Name=4.
Topological domain: 240 268 Extracellular.
Transmembrane: 269 288 Helical; Name=5.
Topological domain: 289 311 Cytoplasmic.
Transmembrane: 312 334 Helical; Name=6.
Topological domain: 335 350 Extracellular.
Transmembrane: 351 374 Helical; Name=7.
Topological domain: 375 425 Cytoplasmic.
Functional site: 41 42 Cleavage; by thrombin.
Protein Length
425 AA.
Protein Sequence
(Canonical)
MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE  60
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN  120
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA  180
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK  240
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS  300
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS  360
SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY  420
KKLLT                                                              425
FASTA
(Canonical)
>LipidDB-9606-01111|P25116
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
Gene Ontology
GO:0005901; C:caveola; IDA:BHF-UCL
GO:0005576; C:extracellular region; TAS:Reactome
GO:0005794; C:Golgi apparatus; TAS:ProtInc
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0031594; C:neuromuscular junction; ISS:UniProtKB
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0031094; C:platelet dense tubular network; IDA:BHF-UCL
GO:0045211; C:postsynaptic membrane; ISS:UniProtKB
GO:0001965; F:G-protein alpha-subunit binding; ISS:UniProtKB
GO:0031681; F:G-protein beta-subunit binding; ISS:UniProtKB
GO:0004930; F:G-protein coupled receptor activity; ISS:UniProtKB
GO:0005102; F:receptor binding; IPI:BHF-UCL
GO:0015057; F:thrombin receptor activity; IDA:BHF-UCL
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL
GO:0000186; P:activation of MAPKK activity; ISS:UniProtKB
GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0002248; P:connective tissue replacement involved in inflammatory response wound healing; IDA:BHF-UCL
GO:0007529; P:establishment of synaptic specificity at neuromuscular junction; ISS:UniProtKB
GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB
GO:0048873; P:homeostasis of number of cells within a tissue; ISS:UniProtKB
GO:0006954; P:inflammatory response; ISS:UniProtKB
GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL
GO:0003105; P:negative regulation of glomerular filtration; ISS:UniProtKB
GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB
GO:1900134; P:negative regulation of renin secretion into blood stream; ISS:UniProtKB
GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IDA:BHF-UCL
GO:0030168; P:platelet activation; IDA:BHF-UCL
GO:0060155; P:platelet dense granule organization; IC:BHF-UCL
GO:0030194; P:positive regulation of blood coagulation; IDA:BHF-UCL
GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB
GO:0030335; P:positive regulation of cell migration; IMP:BHF-UCL
GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB
GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:BHF-UCL
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB
GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; ISS:UniProtKB
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEP:UniProtKB
GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:UniProtKB
GO:2000484; P:positive regulation of interleukin-8 secretion; IDA:UniProtKB
GO:0046427; P:positive regulation of JAK-STAT cascade; IDA:BHF-UCL
GO:0043410; P:positive regulation of MAPK cascade; IDA:BHF-UCL
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:BHF-UCL
GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:UniProtKB
GO:0045987; P:positive regulation of smooth muscle contraction; ISS:UniProtKB
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:BHF-UCL
GO:0045907; P:positive regulation of vasoconstriction; ISS:UniProtKB
GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB
GO:0030193; P:regulation of blood coagulation; IDA:BHF-UCL
GO:0032651; P:regulation of interleukin-1 beta production; ISS:UniProtKB
GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB
GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB
GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB
GO:0009611; P:response to wounding; IDA:BHF-UCL
GO:0007262; P:STAT protein import into nucleus; IDA:BHF-UCL
GO:0007260; P:tyrosine phosphorylation of STAT protein; IDA:BHF-UCL
Interpro
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR003912; Protea_act_rcpt
InterPro; IPR000935; Thrmbn_rcpt
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR01428; PROTEASEAR;
PRINTS; PR00908; THROMBINR;