LipidDB ID

LipidDB-9606-01106

Entry Name

UniProt Accession

P62745; B2R692; P01121; Q5U0H6; Q7RTN5; Q7RTR9; Q9CUV7;

Theoretical PI

5.1

Molecular Weight

22123.39

Genbank Protein ID

CAA29968.1; AAM21118.1; CAG47068.1; BAG54035.1; BAG35389.1; AAV38353.1; AAV38354.1; AAY24345.1; EAX00819.1; EAX00820.1; AAH66954.1; AAA36565.1; DAA01138.1; DAA01912.1;

Genbank Nucleotide ID

X06820; AF498971; CR542272; AK124398; AK312487; BT019546; BT019547; AC023137; CH471053; CH471053; BC066954; M12174; BK001232; BK001671;

Protein Name

Rho-related GTP-binding protein RhoB

Protein Synonyms/Alias

Rho cDNA clone 6; h6;

Gene Name

RHOB

Gene Synonyms/Alias

ARH6; ARHB;

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Wang DA, Sebti SM. Palmitoylated cysteine 192 is required for RhoBtumor-suppressive and apoptotic activities. J Biol Chem. 2005 May13;280(19):19243-9. Epub 2005 Feb 15.[PMID:15713677]
[2] Armstrong SA, Hannah VC, Goldstein JL, Brown MS. CAAX geranylgeranyltransferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J BiolChem. 1995 Apr 7;270(14):7864-8.[PMID:7713879]
[3] Adamson P, Marshall CJ, Hall A, Tilbrook PA. Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8.[PMID:1400319]

Functional Description

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Sequence Annotation

Nucleotide-binding: 12 19 GTP.
Nucleotide-binding: 59 63 GTP.
Nucleotide-binding: 117 120 GTP.
Motif: 34 42 Effector region.
Modified residue: 41 41 ADP-ribosylasparagine; by botulinumtoxin.
Modified residue: 154 154 Phosphotyrosine.
Modified residue: 193 193 Cysteine methyl ester.

Protein Length

196 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0032154; C:cleavage furrow; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0010008; C:endosome membrane; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005634; C:nucleus; ISS:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0019003; F:GDP binding; IEA:Ensembl
GO:0005525; F:GTP binding; TAS:UniProtKB
GO:0003924; F:GTPase activity; TAS:UniProtKB
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; TAS:UniProtKB
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007155; P:cell adhesion; ISS:UniProtKB
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB
GO:0071479; P:cellular response to ionizing radiation; IDA:UniProtKB
GO:0000910; P:cytokinesis; IMP:UniProtKB
GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB
GO:0030168; P:platelet activation; TAS:Reactome
GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB
GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome
GO:0007266; P:Rho protein signal transduction; TAS:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
GO:0006927; P:transformed cell apoptotic process; ISS:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;