Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01100
Entry Name
UniProt Accession
Theoretical PI
5.68
Molecular Weight
103637.91
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Netrin receptor UNC5B
Protein Synonyms/Alias
Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1;
Gene Name
UNC5B
Gene Synonyms/Alias
P53RDL1; UNC5H2; UNQ1883/PRO4326;
Created Date
11-OCT-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
403
Canonical
VVVYRRNCRDFDTDI
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Maisse C, Rossin A, Cahuzac N, Paradisi A, Klein C, Haillot ML, Hérincs Z,Mehlen P, Hueber AO. Lipid raft localization and palmitoylation: identificationof two requirements for cell death induction by the tumor suppressors UNC5H. Exp Cell Res. 2008 Aug 15;314(14):2544-52. doi: 10.1016/j.yexcr.2008.06.001. Epub2008 Jun 7.[PMID:18582460]
Functional Description
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Sequence Annotation
Topological domain: 27 377 Extracellular.
Transmembrane: 378 398 Helical.
Topological domain: 399 945 Cytoplasmic.
Domain: 48 145 Ig-like.
Domain: 147 242 Ig-like C2-type.
Domain: 246 300 TSP type-1 1.
Domain: 302 354 TSP type-1 2.
Domain: 544 688 ZU5.
Domain: 865 943 Death.
Region: 689 838 UPA domain.
Region: 707 725 Interaction with DCC.
Functional site: 412 413 Cleavage; by caspase-3.
Protein Length
945 AA.
Protein Sequence
(Canonical)
MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV  60
KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL  120
FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV  180
PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT  240
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP  300
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQNKKTL  360
SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR RNCRDFDTDI TDSSAALTGG  420
FHPVNFKTAR PSNPQLLHPS VPPDLTASAG IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL  480
KVKVYSSSTT GSGPGLADGA DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD  540
PGSSVSGTFG CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV  600
LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV TLDEETLNTP  660
CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF APALCTSLEY SLRVYCLEDT  720
PVALKEVLEL ERTLGGYLVE EPKPLMFKDS YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY  780
HIWSGSQKAL HCTFTLERHS LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC  840
SAPGSTVTTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA  900
SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC                  945
FASTA
(Canonical)
>LipidDB-9606-01100|Q8IZJ1
MGARSGARGALLLALLLCWDPRLSQAGTDSGSEVLPDSFPSAPAEPLPYFLQEPQDAYIV
KNKPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEEL
FGLEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGV
PVAEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTAT
VIVYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP
VDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTL
SDPNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGG
FHPVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSL
KVKVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRD
PGSSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTV
LSPSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTP
CYCQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDT
PVALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFY
HIWSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLC
SAPGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKA
SPTGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDGDC
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0033564; P:anterior/posterior axon guidance; IEA:Ensembl
GO:0006915; P:apoptotic process; TAS:Reactome
GO:0007411; P:axon guidance; TAS:Reactome
GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB
GO:0043524; P:negative regulation of neuron apoptotic process; IMP:UniProtKB
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:UniProtKB
GO:0042981; P:regulation of apoptotic process; TAS:Reactome
GO:0007165; P:signal transduction; IEA:InterPro
Interpro
InterPro; IPR011029; DEATH-like_dom
InterPro; IPR000488; Death_domain
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR013098; Ig_I-set
InterPro; IPR003598; Ig_sub2
InterPro; IPR000884; Thrombospondin_1_rpt
InterPro; IPR000906; ZU5_dom
Pfam
Pfam; PF00531; Death;
Pfam; PF07679; I-set;
Pfam; PF00090; TSP_1;
Pfam; PF00791; ZU5;
SMART
SMART; SM00005; DEATH;
SMART; SM00408; IGc2;
SMART; SM00209; TSP1;
SMART; SM00218; ZU5;
PROSITE
PROSITE; PS50835; IG_LIKE;
PROSITE; PS50092; TSP1;
PROSITE; PS51145; ZU5;
PRINTS