Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01093
Entry Name
UniProt Accession
Theoretical PI
5.43
Molecular Weight
24635.64
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Regulator of G-protein signaling 19
Protein Synonyms/Alias
RGS19; G-alpha-interacting protein; GAIP;
Gene Name
RGS19
Gene Synonyms/Alias
GAIP; GNAI3IP;
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
39
Canonical
AAPSRNPCCLCWCCC
[1]
S-Palmitoylation
40
Canonical
APSRNPCCLCWCCCC
[1]
S-Palmitoylation
42
Canonical
SRNPCCLCWCCCCSC
[1]
S-Palmitoylation
44
Canonical
NPCCLCWCCCCSCSW
[1]
S-Palmitoylation
45
Canonical
PCCLCWCCCCSCSWN
[1]
S-Palmitoylation
46
Canonical
CCLCWCCCCSCSWNQ
[1]
S-Palmitoylation
47
Canonical
CLCWCCCCSCSWNQE
[1]
S-Palmitoylation
49
Canonical
CWCCCCSCSWNQERR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG. GAIP ismembrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15203-8.[PMID:8986788]
Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Sequence Annotation
Domain: 90 206 RGS.
Region: 207 217 Interaction with GIPC.
Modified residue: 24 24 Phosphoserine.
Modified residue: 97 97 Phosphoserine.
Modified residue: 151 151 Phosphoserine; by MAPK1 and MAPK3.
Protein Length
217 AA.
Protein Sequence
(Canonical)
MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS WNQERRRAWQ  60
ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG RSVFRAFLRT EYSEENMLFW  120
LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINKKMQ EPSAHTFDDA  180
QLQIYTLMHR DSYPRFLSSP TYRALLLQGP SQSSSEA                           217
FASTA
(Canonical)
>LipidDB-9606-01093|P49795
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQ
ASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFW
LACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDA
QLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
Gene Ontology
GO:0005903; C:brush border; IEA:Ensembl
GO:0030136; C:clathrin-coated vesicle; IEA:Ensembl
GO:0005737; C:cytoplasm; IBA:RefGenome
GO:0005794; C:Golgi apparatus; TAS:ProtInc
GO:0016020; C:membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; IBA:RefGenome
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0006914; P:autophagy; IEA:UniProtKB-KW
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0043547; P:positive regulation of GTPase activity; IBA:GOC
GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
Interpro
InterPro; IPR024066; Regulat_G_prot_signal_dom1
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
Pfam
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
PROSITE
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR01301; RGSPROTEIN;