| Tag |
Content |
LipidDB ID |
LipidDB-9606-01082 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.69 |
Molecular Weight |
23255.68 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Regulator of G-protein signaling 4 |
Protein Synonyms/Alias |
RGP4; RGS4; |
Gene Name |
RGS4 |
Gene Synonyms/Alias |
|
Created Date |
01-OCT-1996 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MCKGLAGLP | [1] | S-Palmitoylation | 12 | Canonical | LAGLPASCLRSAKDM | [1] | S-Palmitoylation | 95 | Canonical | NIDFWISCEEYKKIK | [2] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Srinivasa SP, Bernstein LS, Blumer KJ, Linder ME. Plasma membrane localizationis required for RGS4 function in Saccharomyces cerevisiae. Proc Natl Acad Sci U SA. 1998 May 12;95(10):5584-9.[ PMID:9576926]
[2] Osterhout JL, Waheed AA, Hiol A, Ward RJ, Davey PC, Nini L, Wang J, MilliganG, Jones TL, Druey KM. Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box iscritical for RGS16 GTPase accelerating activity and regulation of Gi-coupledsignalling. J Biol Chem. 2003 May 23;278(21):19309-16. Epub 2003 Mar 17. PubMedPMID: 12642592.[ PMID:12642592]
|
Functional Description |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. |
Sequence Annotation |
Domain: 62 178 RGS.
|
Protein Length |
205 AA. |
Protein Sequence
(Canonical) |
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA 60
ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS 120
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLVNP 180
SSCGAEKQKG AKSSADCASL VPQCA 205
|
FASTA
(Canonical) |
>LipidDB-9606-01082|P49798
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWA
ESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS
VQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNP
SSCGAEKQKGAKSSADCASLVPQCA
|
Gene Ontology |
GO:0005737; C:cytoplasm; IBA:RefGenome GO:0005829; C:cytosol; IEA:Ensembl GO:0005886; C:plasma membrane; IBA:RefGenome GO:0043234; C:protein complex; IEA:Ensembl GO:0005516; F:calmodulin binding; TAS:ProtInc GO:0005096; F:GTPase activator activity; IBA:RefGenome GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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