LipidDB ID

LipidDB-9606-01073

Entry Name

UniProt Accession

Q8WTV0; F8W8N0; Q14016; Q52LZ5; Q6KFX4;

Theoretical PI

8.55

Molecular Weight

60877.86

Genbank Protein ID

CAA80277.1; AAQ08185.1; EAW98459.1; AAH80647.1; AAH93732.1; AAI12038.1;

Genbank Nucleotide ID

Z22555; AF515445; AC073593; AC126309; CH471054; BC022087; BC080647; BC093732; BC112037;

Protein Name

Scavenger receptor class B member 1

Protein Synonyms/Alias

SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD36;

Gene Name

SCARB1

Gene Synonyms/Alias

CD36L1; CLA1;

Created Date

10-OCT-2003

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Sequence Annotation

Topological domain: 1 11 Cytoplasmic.
Transmembrane: 12 32 Helical.
Topological domain: 33 443 Extracellular.
Transmembrane: 444 464 Helical.
Topological domain: 465 552 Cytoplasmic.

Protein Length

552 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005901; C:caveola; TAS:BHF-UCL
GO:0009986; C:cell surface; IEA:Ensembl
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0031528; C:microvillus membrane; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0005545; F:1-phosphatidylinositol binding; TAS:BHF-UCL
GO:0034186; F:apolipoprotein A-I binding; IPI:BHF-UCL
GO:0034185; F:apolipoprotein binding; IPI:BHF-UCL
GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl
GO:0070506; F:high-density lipoprotein particle receptor activity; IDA:BHF-UCL
GO:0001530; F:lipopolysaccharide binding; IDA:BHF-UCL
GO:0001875; F:lipopolysaccharide receptor activity; IDA:BHF-UCL
GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL
GO:0001786; F:phosphatidylserine binding; ISS:BHF-UCL
GO:0005215; F:transporter activity; TAS:ProtInc
GO:0044406; P:adhesion of symbiont to host; IMP:BHF-UCL
GO:0006702; P:androgen biosynthetic process; IEA:Ensembl
GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl
GO:0007155; P:cell adhesion; IEA:InterPro
GO:0006707; P:cholesterol catabolic process; IEA:Ensembl
GO:0033344; P:cholesterol efflux; ISS:BHF-UCL
GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL
GO:0070508; P:cholesterol import; ISS:BHF-UCL
GO:0032497; P:detection of lipopolysaccharide; IDA:BHF-UCL
GO:0001935; P:endothelial cell proliferation; IEA:Ensembl
GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL
GO:0034375; P:high-density lipoprotein particle remodeling; ISS:BHF-UCL
GO:0015920; P:lipopolysaccharide transport; IDA:BHF-UCL
GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:GOC
GO:0042157; P:lipoprotein metabolic process; TAS:Reactome
GO:0034383; P:low-density lipoprotein particle clearance; ISS:BHF-UCL
GO:0015914; P:phospholipid transport; ISS:BHF-UCL
GO:0010886; P:positive regulation of cholesterol storage; IDA:BHF-UCL
GO:0010595; P:positive regulation of endothelial cell migration; TAS:BHF-UCL
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL
GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:BHF-UCL
GO:0006898; P:receptor-mediated endocytosis; IDA:GOC
GO:0043654; P:recognition of apoptotic cell; IDA:BHF-UCL
GO:0050764; P:regulation of phagocytosis; IC:BHF-UCL
GO:0010899; P:regulation of phosphatidylcholine catabolic process; ISS:BHF-UCL
GO:0043691; P:reverse cholesterol transport; IEP:BHF-UCL
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0070328; P:triglyceride homeostasis; ISS:BHF-UCL
GO:0016032; P:viral process; IEA:UniProtKB-KW
GO:0042060; P:wound healing; TAS:BHF-UCL

Interpro

InterPro; IPR002159; CD36
InterPro; IPR005428; CD36_antigen

Pfam

Pfam; PF01130; CD36;

SMART

PROSITE

PRINTS

PRINTS; PR01610; CD36ANTIGEN;
PRINTS; PR01609; CD36FAMILY;