LipidDB ID

LipidDB-9606-01070

Entry Name

UniProt Accession

P04899; B3KTZ0; B4DYA0; B4E2X5; Q6B6N3; Q8IZ71;

Theoretical PI

5.34

Molecular Weight

40450.91

Genbank Protein ID

CAA28512.1; AAA52556.1; AAA35894.1; AAA35894.1; AAA35894.1; AAA35894.1; AAA35894.1; AAA35894.1; AAA35894.1; AAA35894.1; AAT78421.1; AAM12620.1; BAG53252.1; BAG53334.1; BAG63662.1; BAG65287.1; EAW65053.1; EAW65055.1; EAW65056.1; AAH12138.1; AAH16995.1; CAA30703.1;

Genbank Nucleotide ID

X04828; J03004; M20593; M20586; M20587; M20588; M20589; M20590; M20591; M20592; AY677118; AF493906; AK096299; AK096595; AK302330; AK304473; AC002077; U73166; U73169; CH471055; CH471055; CH471055; BC012138; BC016995; X07854;

Protein Name

Guanine nucleotide-binding protein G(i) subunit alpha-2

Protein Synonyms/Alias

Adenylate cyclase-inhibiting G alpha protein;

Gene Name

GNAI2

Gene Synonyms/Alias

GNAI2B;

Created Date

13-AUG-1987

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

Sequence Annotation

Nucleotide-binding: 40 47 GTP.
Nucleotide-binding: 176 182 GTP.
Nucleotide-binding: 201 205 GTP.
Nucleotide-binding: 270 273 GTP.
Metal binding site: 47 47 Magnesium.
Metal binding site: 182 182 Magnesium.
Binding site: 327 327 GTP; via amide nitrogen.
Modified residue: 179 179 ADP-ribosylarginine; by cholera toxin.
Modified residue: 352 352 ADP-ribosylcysteine; by pertussis toxin.

Protein Length

355 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005813; C:centrosome; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0016020; C:membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0030496; C:midbody; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:HPA
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl
GO:0001973; P:adenosine receptor signaling pathway; IBA:RefGenome
GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IBA:RefGenome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0051301; P:cell division; IMP:UniProtKB
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:RefGenome
GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc
GO:0050805; P:negative regulation of synaptic transmission; IEA:Ensembl
GO:0030168; P:platelet activation; TAS:Reactome
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl
GO:0007584; P:response to nutrient; TAS:ProtInc
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0007268; P:synaptic transmission; TAS:Reactome

Interpro

InterPro; IPR001408; Gprotein_alpha_I
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00441; GPROTEINAI;