Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01065
Entry Name
UniProt Accession
Theoretical PI
7.83
Molecular Weight
50055.3
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein naked cuticle homolog 2
Protein Synonyms/Alias
Naked-2; hNkd2;
Gene Name
NKD2
Gene Synonyms/Alias
Created Date
11-SEP-2007
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGKLQSKHA
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ. MyristoylatedNaked2 escorts transforming growth factor alpha to the basolateral plasmamembrane of polarized epithelial cells. Proc Natl Acad Sci U S A. 2004 Apr13;101(15):5571-6. Epub 2004 Apr 2.[PMID:15064403]
Functional Description
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
Sequence Annotation
Domain: 119 154 EF-hand.
Region: 2 173 Targeting to the basolateral cellmembrane.
Region: 113 178 Interaction with DVL1, DVL2 and DVL3.
Region: 300 385 Interaction with TGFA.
Protein Length
451 AA.
Protein Sequence
(Canonical)
MGKLQSKHAA AARKRRESPE GDSFVASAYA SGRKGAEEAE RRARDKQELP NGDPKEGPFR  60
EDQCPLQVAL PAEKAEGREH PGQLLSADDG ERAANREGPR GPGGQRLNID ALQCDVSVEE  120
DDRQEWTFTL YDFDNCGKVT REDMSSLMHT IYEVVDASVN HSSGSSKTLR VKLTVSPEPS  180
SKRKEGPPAG QDREPTRCRM EGELAEEPRV ADRRLSAHVR RPSTDPQPCS ERGPYCVDEN  240
TERRNHYLDL AGIENYTSRF GPGSPPVQAK QEPQGRASHL QARSRSQEPD THAVHHRRSQ  300
VLVEHVVPAS EPAARALDTQ PRPKGPEKQF LKSPKGSGKP PGVPASSKSG KAFSYYLPAV  360
LPPQAPQDGH HLPQPPPPPY GHKRYRQKGR EGHSPLKAPH AQPATVEHEV VRDLPPTPAG  420
EGYAVPVIQR HEHHHHHEHH HHHHHHHFHP S                                 451
FASTA
(Canonical)
>LipidDB-9606-01065|Q969F2
MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFR
EDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEE
DDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPS
SKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDEN
TERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQ
VLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAV
LPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAG
EGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS
Gene Ontology
GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL
GO:0071944; C:cell periphery; IDA:BHF-UCL
GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL
GO:0005509; F:calcium ion binding; IEA:InterPro
GO:0019838; F:growth factor binding; IPI:BHF-UCL
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB
GO:0006887; P:exocytosis; IEA:UniProtKB-KW
GO:0048210; P:Golgi vesicle fusion to target membrane; IMP:BHF-UCL
GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:BHF-UCL
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IDA:BHF-UCL
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:BHF-UCL
GO:0010954; P:positive regulation of protein processing; IDA:BHF-UCL
GO:0072661; P:protein targeting to plasma membrane; IMP:BHF-UCL
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW
Interpro
InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR002048; EF_hand_dom
Pfam
SMART
PROSITE
PROSITE; PS50222; EF_HAND_2;
PRINTS