LipidDB ID

LipidDB-9606-01053

Entry Name

UniProt Accession

P16671; D9IX66; D9IX67; D9IX68; D9IX69; Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; Q9BZN4; Q9BZN5;

Theoretical PI

8.19

Molecular Weight

53053.36

Genbank Protein ID

AAA35534.1; AAA58412.1; AAA58413.1; AAA16068.1; AAD13993.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; CAA83662.1; AAM14636.2; ADI80543.1; ADI80544.1; ADI80545.1; ADI80546.1; AAH08406.1; AAG60625.1; AAG60626.1; AAG60627.1; AAG60632.1; AAG60633.1; AAG60634.1; AAG60638.1; AAG60639.1; AAB28992.1; CAA80504.1;

Genbank Nucleotide ID

M24795; M98398; M98399; L06850; S67532; Z32770; Z32754; Z32755; Z32756; Z32757; Z32758; Z32759; Z32760; Z32761; Z32762; Z32763; Z32764; AY095373; HM217023; HM217024; HM217025; HM217026; AC004862; AC073182; AC073850; AC092108; AC124834; BC008406; AF300626; AF300627; AF300628; AF300633; AF300634; AF300635; AF300639; AF300640; S67044; Z22924;

Protein Name

Platelet glycoprotein 4

Protein Synonyms/Alias

Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD36;

Gene Name

CD36

Gene Synonyms/Alias

GP3B; GP4;

Created Date

01-AUG-1990

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Tao N, Wagner SJ, Lublin DM. CD36 is palmitoylated on both N- and C-terminalcytoplasmic tails. J Biol Chem. 1996 Sep 13;271(37):22315-20.[PMID:8798390]

Functional Description

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Sequence Annotation

Topological domain: 2 7 Cytoplasmic.
Transmembrane: 8 29 Helical.
Topological domain: 30 439 Extracellular.
Transmembrane: 440 461 Helical.
Topological domain: 462 472 Cytoplasmic.
Region: 93 120 Required for interaction withthrombospondins, THBS1 and THBS2.
Region: 460 472 Interaction with PTK2, PXN and LYN.
Functional site: 463 463 Critical for TLR4-TLR6 dimerization andsignaling.

Protein Length

472 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0005615; C:extracellular space; IDA:UniProt
GO:0005794; C:Golgi apparatus; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; TAS:BHF-UCL
GO:0016020; C:membrane; TAS:ProtInc
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0045335; C:phagocytic vesicle; TAS:Reactome
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0031092; C:platelet alpha granule membrane; TAS:Reactome
GO:0008035; F:high-density lipoprotein particle binding; IEA:Ensembl
GO:0008289; F:lipid binding; IDA:BHF-UCL
GO:0071813; F:lipoprotein particle binding; IDA:UniProtKB
GO:0070892; F:lipoteichoic acid receptor activity; IEA:Ensembl
GO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL
GO:0005041; F:low-density lipoprotein receptor activity; IMP:BHF-UCL
GO:0070053; F:thrombospondin receptor activity; ISS:BHF-UCL
GO:0050431; F:transforming growth factor beta binding; ISS:BHF-UCL
GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAS:Reactome
GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome
GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome
GO:0043277; P:apoptotic cell clearance; IEA:Ensembl
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007155; P:cell adhesion; TAS:ProtInc
GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl
GO:0044255; P:cellular lipid metabolic process; TAS:Reactome
GO:0071221; P:cellular response to bacterial lipopeptide; IEA:Ensembl
GO:0071447; P:cellular response to hydroperoxide; IEA:Ensembl
GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl
GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl
GO:0019934; P:cGMP-mediated signaling; IDA:BHF-UCL
GO:0030301; P:cholesterol transport; ISS:BHF-UCL
GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl
GO:0045087; P:innate immune response; TAS:Reactome
GO:0006629; P:lipid metabolic process; NAS:ProtInc
GO:0019915; P:lipid storage; IMP:BHF-UCL
GO:0042953; P:lipoprotein transport; IMP:BHF-UCL
GO:0044539; P:long-chain fatty acid import; IDA:UniProtKB
GO:0034383; P:low-density lipoprotein particle clearance; IMP:BHF-UCL
GO:0055096; P:low-density lipoprotein particle mediated signaling; IEA:Ensembl
GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome
GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl
GO:0042992; P:negative regulation of transcription factor import into nucleus; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL
GO:0006910; P:phagocytosis, recognition; IEA:Ensembl
GO:0034381; P:plasma lipoprotein particle clearance; ISS:BHF-UCL
GO:0015911; P:plasma membrane long-chain fatty acid transport; IDA:BHF-UCL
GO:0030168; P:platelet activation; TAS:Reactome
GO:0002576; P:platelet degranulation; TAS:Reactome
GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl
GO:2000334; P:positive regulation of blood microparticle formation; IEA:Ensembl
GO:0001954; P:positive regulation of cell-matrix adhesion; IDA:BHF-UCL
GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl
GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl
GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl
GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl
GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IMP:BHF-UCL
GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl
GO:0060100; P:positive regulation of phagocytosis, engulfment; IEA:Ensembl
GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl
GO:2000121; P:regulation of removal of superoxide radicals; IEA:Ensembl
GO:0035634; P:response to stilbenoid; IEA:Ensembl
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome
GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome
GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome
GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome
GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome

Interpro

InterPro; IPR002159; CD36
InterPro; IPR005428; CD36_antigen

Pfam

Pfam; PF01130; CD36;

SMART

PROSITE

PRINTS

PRINTS; PR01610; CD36ANTIGEN;
PRINTS; PR01609; CD36FAMILY;