LipidDB ID

LipidDB-9606-01028

Entry Name

UniProt Accession

Q9UNN8; B2RC04; Q14218; Q6IB56; Q96CB3; Q9ULX1;

Theoretical PI

6.7

Molecular Weight

26671.44

Genbank Protein ID

AAA63647.1; CAA61450.1; AAD43967.1; BAA77249.2; CAG33229.1; AAK53045.1; BAG37401.1; CAC16283.1; EAW76224.1; AAH14451.1;

Genbank Nucleotide ID

L35545; X89079; AF106202; AB026584; CR456948; AF375468; AK314887; AL356652; CH471077; BC014451;

Protein Name

Endothelial protein C receptor

Protein Synonyms/Alias

Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD201;

Gene Name

PROCR

Gene Synonyms/Alias

EPCR;

Created Date

27-APR-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Sequence Annotation

Topological domain: 18 210 Extracellular.
Transmembrane: 211 231 Helical.
Topological domain: 232 238 Cytoplasmic.

Protein Length

238 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005813; C:centrosome; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0004872; F:receptor activity; TAS:ProtInc
GO:0019882; P:antigen processing and presentation; IEA:InterPro
GO:0007596; P:blood coagulation; IEA:UniProtKB-KW
GO:0006955; P:immune response; IEA:InterPro
GO:0050819; P:negative regulation of coagulation; IMP:BHF-UCL

Interpro

InterPro; IPR015669; Endothetial_C_recpt
InterPro; IPR011161; MHC_I-like_Ag-recog
InterPro; IPR011162; MHC_I/II-like_Ag-recog
InterPro; IPR001039; MHC_I_a_a1/a2

Pfam

Pfam; PF00129; MHC_I;

SMART

PROSITE

PRINTS