LipidDB ID

LipidDB-9606-01007

Entry Name

UniProt Accession

Q9NRR3; B2R622; Q4KMT9;

Theoretical PI

8.61

Molecular Weight

9223.49

Genbank Protein ID

AAF87598.1; BAG35319.1; EAW62373.1; AAH96703.1; AAH96738.1; AAH98349.1;

Genbank Nucleotide ID

AF189692; AK312406; CH471062; BC096703; BC096738; BC098349;

Protein Name

CDC42 small effector protein 2

Protein Synonyms/Alias

Small effector of CDC42 protein 2;

Gene Name

CDC42SE2

Gene Synonyms/Alias

SPEC2;

Created Date

20-MAY-2008

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Ching KH, Kisailus AE, Burbelo PD. The role of SPECs, small Cdc42-bindingproteins, in F-actin accumulation at the immunological synapse. J Biol Chem. 2005Jun 24;280(25):23660-7. Epub 2005 Apr 19.[PMID:15840583]

Functional Description

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

Sequence Annotation

Domain: 29 42 CRIB.

Protein Length

84 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0042995; C:cell projection; IEA:UniProtKB-KW
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005198; F:structural molecule activity; IDA:UniProtKB
GO:0006909; P:phagocytosis; IEA:UniProtKB-KW
GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW
GO:0009966; P:regulation of signal transduction; IDA:UniProtKB

Interpro

InterPro; IPR000095; CRIB_dom

Pfam

Pfam; PF00786; PBD;

SMART

PROSITE

PROSITE; PS50108; CRIB;

PRINTS