Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-01004
Entry Name
UniProt Accession
Theoretical PI
9.28
Molecular Weight
40981.71
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Proto-oncogene Wnt-1
Protein Synonyms/Alias
Proto-oncogene Int-1 homolog;
Gene Name
WNT1
Gene Synonyms/Alias
INT1;
Created Date
13-AUG-1987
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
93
Canonical
LQSAVRECKWQFRNR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T,Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. Fatty acidmodification of Wnt1 and Wnt3a at serine is prerequisite for lipidation atcysteine and is essential for Wnt signalling. Cell Signal. 2011 May;23(5):837-48.doi: 10.1016/j.cellsig.2011.01.007. Epub 2011 Jan 16.[PMID:21244856]
Functional Description
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.
Sequence Annotation
Protein Length
370 AA.
Protein Sequence
(Canonical)
MGLWALLPGW VSATLLLALA ALPAALAANS SGRWWGIVNV ASSTNLLTDS KSLQLVLEPS  60
LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG  120
CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF  180
GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR  240
AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT  300
YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC  360
THTRVLHECL                                                         370
FASTA
(Canonical)
>LipidDB-9606-01004|P04628
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
Gene Ontology
GO:0009986; C:cell surface; IEA:Ensembl
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome
GO:0005576; C:extracellular region; TAS:Reactome
GO:0005615; C:extracellular space; IBA:RefGenome
GO:0005796; C:Golgi lumen; TAS:Reactome
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-KW
GO:0005125; F:cytokine activity; ISS:BHF-UCL
GO:0005109; F:frizzled binding; IC:BHF-UCL
GO:0048018; F:receptor agonist activity; IC:BHF-UCL
GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB
GO:0060348; P:bone development; IMP:UniProtKB
GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl
GO:0060070; P:canonical Wnt signaling pathway; IMP:BHF-UCL
GO:0044336; P:canonical Wnt signaling pathway involved in negative regulation of apoptotic process; IMP:BHF-UCL
GO:0045165; P:cell fate commitment; IBA:RefGenome
GO:0007267; P:cell-cell signaling; ISS:BHF-UCL
GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Ensembl
GO:0021551; P:central nervous system morphogenesis; ISS:BHF-UCL
GO:0021588; P:cerebellum formation; ISS:BHF-UCL
GO:0021536; P:diencephalon development; IEA:Ensembl
GO:0000578; P:embryonic axis specification; ISS:BHF-UCL
GO:0021797; P:forebrain anterior/posterior pattern specification; IEA:Ensembl
GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl
GO:0070365; P:hepatocyte differentiation; IEA:Ensembl
GO:0042472; P:inner ear morphogenesis; IEA:Ensembl
GO:0030901; P:midbrain development; ISS:BHF-UCL
GO:0022004; P:midbrain-hindbrain boundary maturation during brain development; IEA:Ensembl
GO:0007520; P:myoblast fusion; IEA:Ensembl
GO:0030514; P:negative regulation of BMP signaling pathway; IMP:AgBase
GO:0090344; P:negative regulation of cell aging; IDA:BHF-UCL
GO:0022408; P:negative regulation of cell-cell adhesion; IMP:BHF-UCL
GO:0010812; P:negative regulation of cell-substrate adhesion; IDA:BHF-UCL
GO:0045599; P:negative regulation of fat cell differentiation; ISS:BHF-UCL
GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl
GO:0030182; P:neuron differentiation; IBA:RefGenome
GO:0048664; P:neuron fate determination; IEA:Ensembl
GO:0031100; P:organ regeneration; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL
GO:0061184; P:positive regulation of dermatome development; IDA:BHF-UCL
GO:0048146; P:positive regulation of fibroblast proliferation; IMP:BHF-UCL
GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IDA:BHF-UCL
GO:0010592; P:positive regulation of lamellipodium assembly; IMP:BHF-UCL
GO:0045747; P:positive regulation of Notch signaling pathway; IDA:BHF-UCL
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB
GO:0009611; P:response to wounding; IEP:UniProtKB
GO:0042770; P:signal transduction in response to DNA damage; IDA:BHF-UCL
GO:0060061; P:Spemann organizer formation; ISS:BHF-UCL
GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl
GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl
GO:0030579; P:ubiquitin-dependent SMAD protein catabolic process; IEA:Ensembl
GO:0016055; P:Wnt signaling pathway; IDA:BHF-UCL
Interpro
InterPro; IPR005817; Wnt
InterPro; IPR009139; Wnt1
InterPro; IPR018161; Wnt_CS
Pfam
Pfam; PF00110; wnt;
SMART
SMART; SM00097; WNT1;
PROSITE
PROSITE; PS00246; WNT1;
PRINTS
PRINTS; PR01841; WNT1PROTEIN;
PRINTS; PR01349; WNTPROTEIN;