| Tag |
Content |
LipidDB ID |
LipidDB-9606-00999 |
Entry Name |
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UniProt Accession |
|
Theoretical PI |
6.89 |
Molecular Weight |
14632.22 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
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Protein Name |
Interferon-induced transmembrane protein 2 |
Protein Synonyms/Alias |
Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D; |
Gene Name |
IFITM2 |
Gene Synonyms/Alias |
|
Created Date |
01-JUL-1993 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
70 | Canonical | NTLFMNTCCLGFIAF | [1] | S-Palmitoylation | 71 | Canonical | TLFMNTCCLGFIAFA | [1] | S-Palmitoylation | 104 | Canonical | AYASTAKCLNIWALI | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Chutiwitoonchai N, Hiyoshi M, Hiyoshi-Yoshidomi Y, Hashimoto M, Tokunaga K,Suzu S. Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1family proteins. Microbes Infect. 2013 Apr;15(4):280-90. doi:10.1016/j.micinf.2012.12.003. Epub 2013 Jan 30.[ PMID:23376165]
|
Functional Description |
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. |
Sequence Annotation |
Topological domain: 1 56 Cytoplasmic.
Topological domain: 78 106 Cytoplasmic.
Transmembrane: 107 127 Helical.
Topological domain: 128 132 Extracellular.
Modified residue: 1 1 N-acetylmethionine.
|
Protein Length |
132 AA. |
Protein Sequence
(Canonical) |
MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS 60
LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL 120
IIIPVLVVQA QR 132
|
FASTA
(Canonical) |
>LipidDB-9606-00999|Q01629
MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGVPHNPAPPMSTVIHIRSETSVPDHVVWS
LFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGIFMTILL
IIIPVLVVQAQR
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; TAS:Reactome GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome GO:0051607; P:defense response to virus; IEA:UniProtKB-KW GO:0006955; P:immune response; TAS:ProtInc GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB GO:0045071; P:negative regulation of viral genome replication; IDA:UniProtKB GO:0035455; P:response to interferon-alpha; IDA:UniProtKB GO:0035456; P:response to interferon-beta; IDA:UniProtKB GO:0034341; P:response to interferon-gamma; IDA:UniProtKB GO:0009615; P:response to virus; IDA:UniProtKB GO:0060337; P:type I interferon signaling pathway; TAS:Reactome |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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