LipidDB ID

LipidDB-9606-00996

Entry Name

UniProt Accession

P01135; A8K286; Q15577; Q53SK7; Q9BS56; Q9UEI3; Q9UKM1; Q9UKM2; Q9UKM3;

Theoretical PI

7.51

Molecular Weight

17005.98

Genbank Protein ID

AAA61159.1; AAA61157.1; CAA49806.1; AAF13491.1; AAF13491.1; AAF13491.1; AAF13491.1; AAF13491.1; AAF13491.1; AAP97822.2; AAP97822.2; AAP97822.2; AAP97822.2; AAP97822.2; AAP97822.2; AAF05089.1; AAF05090.1; AAF05091.1; AAP35479.1; BAF82840.1; AAY14793.1; AAY14705.1; EAW99810.1; EAW99812.1; AAH05308.1; AAA52530.1; AAD12238.1; AAD12238.1;

Genbank Nucleotide ID

K03222; M31172; X70340; AF123243; AF123238; AF123239; AF123240; AF123241; AF123242; AY325886; AY325885; AY326405; AY327131; AY327132; AY329368; AF149096; AF149097; AF149098; BT006833; AK290151; AC005234; AC017084; CH471053; CH471053; BC005308; M22440; AF075584; AF075583;

Protein Name

Transforming growth factor alpha

Protein Synonyms/Alias

TGF-alpha; EGF-like TGF; ETGF; TGF type 1;

Gene Name

TGFA

Gene Synonyms/Alias

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Shum L, Turck CW, Derynck R. Cysteines 153 and 154 of transmembranetransforming growth factor-alpha are palmitoylated and mediate cytoplasmicprotein association. J Biol Chem. 1996 Nov 8;271(45):28502-8.[PMID:8910478]

Functional Description

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Sequence Annotation

Topological domain: 24 98 Extracellular.
Transmembrane: 99 124 Helical.
Topological domain: 125 160 Cytoplasmic.
Domain: 43 83 EGF-like.

Protein Length

160 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016323; C:basolateral plasma membrane; IDA:BHF-UCL
GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL
GO:0005615; C:extracellular space; IDA:BHF-UCL
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL
GO:0005886; C:plasma membrane; NAS:ProtInc
GO:0005154; F:epidermal growth factor receptor binding; IDA:UniProtKB
GO:0008083; F:growth factor activity; IDA:HGNC
GO:0004708; F:MAP kinase kinase activity; IDA:HGNC
GO:0000187; P:activation of MAPK activity; IDA:HGNC
GO:0001525; P:angiogenesis; IEA:Ensembl
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl
GO:0060749; P:mammary gland alveolus development; IEA:Ensembl
GO:0000165; P:MAPK cascade; IDA:GOC
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW
GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; IDA:HGNC
GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:HGNC
GO:0045840; P:positive regulation of mitosis; IDA:HGNC
GO:0042493; P:response to drug; IEA:Ensembl
GO:0042060; P:wound healing; IEA:Ensembl

Interpro

InterPro; IPR000742; EG-like_dom
InterPro; IPR013032; EGF-like_CS
InterPro; IPR015497; EGF_rcpt_ligand

Pfam

SMART

SMART; SM00181; EGF;

PROSITE

PROSITE; PS00022; EGF_1;
PROSITE; PS01186; EGF_2;
PROSITE; PS50026; EGF_3;

PRINTS