LipidDB-9606-00993

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00993

Entry Name

ARF3_HUMAN

UniProt Accession

P61204; A8K6G8; B7ZB63; P16587;

Theoretical PI

6.84

Molecular Weight

20600.76

Genbank Protein ID

AAA58359.1; AAA83931.1; AAB59425.1; AAM12596.1; AAP35316.1; BAF84322.1; BAH14899.1; EAW58026.1; AAH07647.1; AAH07762.1; AAH17565.1; AAH28402.1;

Genbank Nucleotide ID

M74493; M33384; M74491; AF493882; BT006670; AK291633; AK316528; AC073610; CH471111; BC007647; BC007762; BC017565; BC028402;

Protein Name

ADP-ribosylation factor 3

Protein Synonyms/Alias

Gene Name

ARF3

Gene Synonyms/Alias

Created Date

10-MAY-2004

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
2	Canonical	******MGNIFGNLL	[1]	N-Myristoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Resh MD. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta. 1999 Aug12;1451(1):1-16. Review.[PMID:10446384]

Functional Description

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Sequence Annotation

Nucleotide-binding: 24 31 GTP.
Nucleotide-binding: 67 71 GTP.
Nucleotide-binding: 126 129 GTP.

Protein Length

181 AA.

Protein Sequence
(Canonical)

MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN  60
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV  120
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK  180
K                                                                  181

FASTA
(Canonical)

>LipidDB-9606-00993|P61204
MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV
LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNK
K

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0000139; C:Golgi membrane; TAS:Reactome
GO:0005525; F:GTP binding; TAS:ProtInc
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome
GO:0006644; P:phospholipid metabolic process; TAS:Reactome
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR

Pfam

Pfam; PF00025; Arf;

SMART

SMART; SM00177; ARF;

PROSITE

PROSITE; PS51417; ARF;

PRINTS

PRINTS; PR00328; SAR1GTPBP;