Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00989
Entry Name
UniProt Accession
Theoretical PI
5.65
Molecular Weight
57029.06
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Fibroblast growth factor receptor substrate 2
Protein Synonyms/Alias
FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1;
Gene Name
FRS2
Gene Synonyms/Alias
Created Date
19-JUL-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGSCCSCPD
[1][2]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Xu H, Lee KW, Goldfarb M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. JBiol Chem. 1998 Jul 17;273(29):17987-90.[PMID:9660748]
[2] Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM. The signaling adapterFRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. Amodel for discriminating proliferation and differentiation. J Biol Chem. 1999 Apr2;274(14):9861-70.[PMID:10092678]
Functional Description
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Sequence Annotation
Domain: 13 115 IRS-type PTB.
Modified residue: 196 196 Phosphotyrosine; by FGFR1.
Modified residue: 211 211 Phosphoserine.
Modified residue: 221 221 Phosphoserine.
Modified residue: 306 306 Phosphotyrosine; by FGFR1.
Modified residue: 349 349 Phosphotyrosine; by FGFR1.
Modified residue: 392 392 Phosphotyrosine; by FGFR1.
Modified residue: 436 436 Phosphotyrosine; by FGFR1.
Modified residue: 471 471 Phosphotyrosine; by FGFR1.
Protein Length
508 AA.
Protein Sequence
(Canonical)
MGSCCSCPDK DTVPDNHRNK FKVINVDDDG NELGSGIMEL TDTELILYTR KRDSVKWHYL  60
CLRRYGYDSN LFSFESGRRC QTGQGIFAFK CARAEELFNM LQEIMQNNSI NVVEEPVVER  120
NNHQTELEVP RTPRTPTTPG FAAQNLPNGY PRYPSFGDAS SHPSSRHPSV GSARLPSVGE  180
ESTHPLLVAE EQVHTYVNTT GVQEERKNRT SVHVPLEARV SNAESSTPKE EPSSIEDRDP  240
QILLEPEGVK FVLGPTPVQK QLMEKEKLEQ LGRDQVSGSG ANNTEWDTGY DSDERRDAPS  300
VNKLVYENIN GLSIPSASGV RRGRLTSTST SDTQNINNSA QRRTALLNYE NLPSLPPVWE  360
ARKLSRDEDD NLGPKTPSLN GYHNNLDPMH NYVNTENVTV PASAHKIEYS RRRDCTPTVF  420
NFDIRRPSLE HRQLNYIQVD LEGGSDSDNP QTPKTPTTPL PQTPTRRTEL YAVIDIERTA  480
AMSNLQKALP RDDGTSRKTR HNSTDLPM                                     508
FASTA
(Canonical)
>LipidDB-9606-00989|Q8WU20
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTRKRDSVKWHYL
CLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVER
NNHQTELEVPRTPRTPTTPGFAAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGE
ESTHPLLVAEEQVHTYVNTTGVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDP
QILLEPEGVKFVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPS
VNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYENLPSLPPVWE
ARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIEYSRRRDCTPTVF
NFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTA
AMSNLQKALPRDDGTSRKTRHNSTDLPM
Gene Ontology
GO:0005911; C:cell-cell junction; IEA:Ensembl
GO:0005768; C:endosome; TAS:Reactome
GO:0005887; C:integral component of plasma membrane; TAS:UniProtKB
GO:0016020; C:membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005104; F:fibroblast growth factor receptor binding; IPI:MGI
GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB
GO:0019211; F:phosphatase activator activity; TAS:UniProtKB
GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; TAS:UniProtKB
GO:0000187; P:activation of MAPK activity; IEA:Ensembl
GO:0000186; P:activation of MAPKK activity; TAS:Reactome
GO:0008595; P:anterior/posterior axis specification, embryo; IEA:Ensembl
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:UniProtKB
GO:0030900; P:forebrain development; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB
GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl
GO:0045087; P:innate immune response; TAS:Reactome
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome
GO:0070307; P:lens fiber cell development; IEA:Ensembl
GO:0007405; P:neuroblast proliferation; IEA:Ensembl
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0046619; P:optic placode formation involved in camera-type eye formation; IEA:Ensembl
GO:0001759; P:organ induction; IEA:Ensembl
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IEA:Ensembl
GO:0042981; P:regulation of apoptotic process; IEA:Ensembl
GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl
GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl
GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:UniProtKB
GO:0003281; P:ventricular septum development; IEA:Ensembl
Interpro
InterPro; IPR002404; Insln_rcpt_S1
InterPro; IPR011993; PH_like_dom
Pfam
Pfam; PF02174; IRS;
SMART
SMART; SM00310; PTBI;
PROSITE
PROSITE; PS51064; IRS_PTB;
PRINTS