Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00981
Entry Name
UniProt Accession
Theoretical PI
7.98
Molecular Weight
54847.84
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Fatty aldehyde dehydrogenase
Protein Synonyms/Alias
1.2.1.3; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase;
Gene Name
ALDH3A2
Gene Synonyms/Alias
ALDH10; FALDH;
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
241
Canonical
YMNCGQTCIAPDYIL
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Sequence Annotation
Topological domain: 1 463 Cytoplasmic.
Transmembrane: 464 480 Helical.
Nucleotide-binding: 185 190 NAD.
Active site: 207 207
Active site: 241 241
Protein Length
485 AA.
Protein Sequence
(Canonical)
MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE  60
VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ  120
PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH  180
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT  240
CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI  300
AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA  360
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS  420
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV  480
KAEYY                                                              485
FASTA
(Canonical)
>LipidDB-9606-00981|P51648
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE
VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ
PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH
IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT
CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI
AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA
LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS
HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLV
KAEYY
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB
GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl
GO:0005777; C:peroxisome; IDA:UniProtKB
GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:UniProtKB
GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro
GO:0046577; F:long-chain-alcohol oxidase activity; IDA:UniProtKB
GO:0050061; F:long-chain-aldehyde dehydrogenase activity; IDA:UniProtKB
GO:0052814; F:medium-chain-aldehyde dehydrogenase activity; IDA:UniProtKB
GO:0006081; P:cellular aldehyde metabolic process; IDA:UniProtKB
GO:0007417; P:central nervous system development; IMP:UniProtKB
GO:0008544; P:epidermis development; IMP:UniProtKB
GO:0055114; P:oxidation-reduction process; IDA:GOC
GO:0007422; P:peripheral nervous system development; IMP:UniProtKB
GO:0033306; P:phytol metabolic process; IMP:UniProtKB
GO:0006714; P:sesquiterpenoid metabolic process; IDA:UniProtKB
Interpro
InterPro; IPR016161; Ald_DH/histidinol_DH
InterPro; IPR016163; Ald_DH_C
InterPro; IPR016160; Ald_DH_CS_CYS
InterPro; IPR029510; Ald_DH_CS_GLU
InterPro; IPR016162; Ald_DH_N
InterPro; IPR015590; Aldehyde_DH_dom
InterPro; IPR012394; Aldehyde_DH_NAD(P)
Pfam
Pfam; PF00171; Aldedh;
SMART
PROSITE
PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS;
PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU;
PRINTS