LipidDB ID

LipidDB-9606-00963

Entry Name

UniProt Accession

P46013; Q5VWH2;

Theoretical PI

9.49

Molecular Weight

358693.66

Genbank Protein ID

CAA46519.1; CAA46520.1; CAH73169.1; CAH73169.1; CAA64388.1;

Genbank Nucleotide ID

X65550; X65551; AL390236; AL355529; X94762;

Protein Name

Antigen KI-67

Protein Synonyms/Alias

Gene Name

MKI67

Gene Synonyms/Alias

Created Date

01-NOV-1995

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Thought to be required for maintaining cell proliferation.

Sequence Annotation

Domain: 27 76 FHA.
Nucleotide-binding: 3034 3041 ATP.
Region: 1000 2928 16 X 122 AA approximate repeats.
Modified residue: 125 125 Phosphoserine.
Modified residue: 264 264 Phosphoserine.
Modified residue: 308 308 Phosphoserine.
Modified residue: 328 328 Phosphothreonine.
Modified residue: 347 347 Phosphothreonine.
Modified residue: 352 352 Phosphoserine.
Modified residue: 357 357 Phosphoserine.
Modified residue: 401 401 Phosphothreonine.
Modified residue: 579 579 Phosphoserine.
Modified residue: 584 584 Phosphoserine.
Modified residue: 648 648 Phosphoserine.
Modified residue: 761 761 Phosphothreonine.
Modified residue: 859 859 Phosphoserine.
Modified residue: 1017 1017 Phosphothreonine.
Modified residue: 1071 1071 Phosphoserine.
Modified residue: 1091 1091 Phosphothreonine.
Modified residue: 1098 1098 Phosphoserine.
Modified residue: 1111 1111 Phosphothreonine.
Modified residue: 1131 1131 Phosphoserine.
Modified residue: 1139 1139 Phosphothreonine.
Modified residue: 1142 1142 Phosphoserine.
Modified residue: 1167 1167 Phosphothreonine.
Modified residue: 1193 1193 Phosphothreonine.
Modified residue: 1207 1207 Phosphoserine.
Modified residue: 1233 1233 Phosphothreonine.
Modified residue: 1253 1253 Phosphoserine.
Modified residue: 1256 1256 Phosphoserine.
Modified residue: 1261 1261 Phosphothreonine.
Modified residue: 1298 1298 Phosphothreonine.
Modified residue: 1315 1315 Phosphothreonine.
Modified residue: 1327 1327 Phosphothreonine.
Modified residue: 1329 1329 Phosphoserine.
Modified residue: 1335 1335 Phosphothreonine.
Modified residue: 1355 1355 Phosphothreonine.
Modified residue: 1376 1376 Phosphoserine.
Modified residue: 1383 1383 Phosphothreonine.
Modified residue: 1496 1496 Phosphoserine.
Modified residue: 1503 1503 Phosphothreonine.
Modified residue: 1506 1506 Phosphoserine.
Modified residue: 1540 1540 Phosphothreonine.
Modified residue: 1552 1552 Phosphotyrosine.
Modified residue: 1557 1557 Phosphothreonine.
Modified residue: 1569 1569 Phosphothreonine.
Modified residue: 1571 1571 Phosphoserine.
Modified residue: 1639 1639 N6-acetyllysine.
Modified residue: 1679 1679 Phosphoserine.
Modified residue: 1689 1689 Phosphoserine.
Modified residue: 1719 1719 Phosphothreonine.
Modified residue: 1721 1721 Phosphoserine.
Modified residue: 1740 1740 Phosphoserine.
Modified residue: 1747 1747 Phosphothreonine.
Modified residue: 1764 1764 Phosphothreonine.
Modified residue: 1784 1784 Phosphothreonine.
Modified residue: 1801 1801 Phosphothreonine.
Modified residue: 1815 1815 Phosphoserine.
Modified residue: 1841 1841 Phosphothreonine.
Modified residue: 1861 1861 Phosphoserine.
Modified residue: 1864 1864 Phosphoserine.
Modified residue: 1869 1869 Phosphothreonine.
Modified residue: 1897 1897 Phosphothreonine.
Modified residue: 1923 1923 Phosphothreonine.
Modified residue: 1937 1937 Phosphoserine.
Modified residue: 1963 1963 Phosphothreonine.
Modified residue: 1983 1983 Phosphoserine.
Modified residue: 2005 2005 N6-acetyllysine.
Modified residue: 2065 2065 Phosphothreonine.
Modified residue: 2072 2072 Phosphoserine.
Modified residue: 2085 2085 Phosphothreonine.
Modified residue: 2105 2105 Phosphoserine.
Modified residue: 2113 2113 Phosphothreonine.
Modified residue: 2135 2135 Phosphoserine.
Modified residue: 2203 2203 Phosphothreonine.
Modified residue: 2223 2223 Phosphoserine.
Modified residue: 2231 2231 Phosphothreonine.
Modified residue: 2233 2233 Phosphothreonine.
Modified residue: 2239 2239 Phosphoserine.
Modified residue: 2268 2268 Phosphothreonine.
Modified residue: 2285 2285 Phosphothreonine.
Modified residue: 2325 2325 Phosphothreonine.
Modified residue: 2328 2328 Phosphothreonine.
Modified residue: 2333 2333 Phosphothreonine.
Modified residue: 2344 2344 Phosphoserine.
Modified residue: 2352 2352 Phosphothreonine.
Modified residue: 2389 2389 Phosphothreonine.
Modified residue: 2395 2395 Phosphoserine.
Modified residue: 2406 2406 Phosphothreonine.
Modified residue: 2420 2420 Phosphoserine.
Modified residue: 2446 2446 Phosphothreonine.
Modified residue: 2528 2528 Phosphoserine.
Modified residue: 2588 2588 Phosphoserine.
Modified residue: 2708 2708 Phosphoserine.
Modified residue: 2827 2827 Phosphoserine.
Modified residue: 2828 2828 Phosphoserine.
Modified residue: 3041 3041 Phosphoserine.
Modified residue: 3128 3128 Phosphoserine.

Protein Length

3256 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0000775; C:chromosome, centromeric region; IEA:Ensembl
GO:0000793; C:condensed chromosome; IEA:Ensembl
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005730; C:nucleolus; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB
GO:0008283; P:cell proliferation; TAS:UniProtKB
GO:0034605; P:cellular response to heat; IEA:Ensembl
GO:0006259; P:DNA metabolic process; IEA:Ensembl
GO:0030212; P:hyaluronan metabolic process; IEA:Ensembl
GO:0007126; P:meiotic nuclear division; IEA:Ensembl
GO:0031100; P:organ regeneration; IEA:Ensembl
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl

Interpro

InterPro; IPR000253; FHA_dom
InterPro; IPR012568; K167R
InterPro; IPR029334; PP1-bd
InterPro; IPR008984; SMAD_FHA_domain

Pfam

Pfam; PF00498; FHA;
Pfam; PF08065; K167R;
Pfam; PF15276; PP1_bind;

SMART

SMART; SM00240; FHA;

PROSITE

PROSITE; PS50006; FHA_DOMAIN;

PRINTS