Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00959
Entry Name
UniProt Accession
Theoretical PI
5.32
Molecular Weight
158298.11
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein LAP2
Protein Synonyms/Alias
Densin-180-like protein; Erbb2-interacting protein; Erbin;
Gene Name
ERBB2IP
Gene Synonyms/Alias
ERBIN; KIAA1225; LAP2;
Created Date
19-JUL-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
14
Canonical
LFVRLVPCRCLRGEE
[1]
S-Palmitoylation
16
Canonical
VRLVPCRCLRGEEET
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Izawa I, Nishizawa M, Hayashi Y, Inagaki M. Palmitoylation of ERBIN isrequired for its plasma membrane localization. Genes Cells. 2008Jul;13(7):691-701. doi: 10.1111/j.1365-2443.2008.01198.x. Epub 2008 May 21.[PMID:18498353]
Functional Description
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
Sequence Annotation
Domain: 1321 1410 PDZ.
Modified residue: 440 440 Phosphoserine.
Modified residue: 569 569 Phosphoserine.
Modified residue: 602 602 Phosphoserine.
Modified residue: 603 603 Phosphoserine.
Modified residue: 715 715 Phosphoserine.
Modified residue: 857 857 Phosphoserine.
Modified residue: 872 872 Phosphoserine.
Modified residue: 917 917 Phosphothreonine.
Modified residue: 920 920 Phosphotyrosine.
Modified residue: 931 931 Phosphoserine.
Modified residue: 972 972 Phosphotyrosine.
Modified residue: 1104 1104 Phosphotyrosine.
Modified residue: 1158 1158 Phosphoserine.
Modified residue: 1286 1286 Phosphoserine.
Protein Length
1412 AA.
Protein Sequence
(Canonical)
MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE  60
LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV  120
EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM  180
NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN  240
NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS  300
VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL  360
PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM  420
VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL  480
KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT  540
TVKSKVDERE KYMIGNSVQK ISEPEAEISP GSLPVTANMK ASENLKHIVN HDDVFEESEE  600
LSSDEEMKMA EMRPPLIETS INQPKVVALS NNKKDDTKET DSLSDEVTHN SNQNNSNCSS  660
PSRMSDSVSL NTDSSQDTSL CSPVKQTHID INSKIRQEDE NFNSLLQNGD ILNSSTEEKF  720
KAHDKKDFNL PEYDLNVEER LVLIEKSVDS TATADDTHKL DHINMNLNKL ITNDTFQPEI  780
MERSKTQDIV LGTSFLSINS KEETEHLENG NKYPNLESVN KVNGHSEETS QSPNRTEPHD  840
SDCSVDLGIS KSTEDLSPQK SGPVGSVVKS HSITNMEIGG LKIYDILSDN GPQQPSTTVK  900
ITSAVDGKNI VRSKSATLLY DQPLQVFTGS SSSSDLISGT KAIFKFDSNH NPEEPNIIRG  960
PTSGPQSAPQ IYGPPQYNIQ YSSSAAVKDT LWHSKQNPQI DHASFPPQLL PRSESTENQS  1020
YAKHSANMNF SNHNNVRANT AYHLHQRLGP ARHGEMWAIS PNDRLIPAVT RSTIQRQSSV  1080
SSTASVNLGD PGSTRRAQIP EGDYLSYREF HSAGRTPPMM PGSQRPLSAR TYSIDGPNAS  1140
RPQSARPSIN EIPERTMSVS DFNYSRTSPS KRPNARVGSE HSLLDPPGKS KVPRDWREQV  1200
LRHIEAKKLE KKHPQTSSSG DPCQDGIFIS GQQNYSSATL SHKDVPPDSL MKMPLSNGQM  1260
GQPLRPQANY SQIHHPPQAS VARHPSREQL IDYLMLKVAH QPPYTQPHCS PRQGHELAKQ  1320
EIRVRVEKDP ELGFSISGGV GGRGNPFRPD DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG  1380
YSFINIEHGQ AVSLLKTFQN TVELIIVREV SS                                1412
FASTA
(Canonical)
>LipidDB-9606-00959|Q96RT1
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE
LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV
EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS
VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE
LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS
PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI
MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS
YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS
RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
LRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQM
GQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQ
EIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANG
YSFINIEHGQAVSLLKTFQNTVELIIVREVSS
Gene Ontology
GO:0009925; C:basal plasma membrane; NAS:UniProtKB
GO:0005604; C:basement membrane; TAS:ProtInc
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0030056; C:hemidesmosome; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:HPA
GO:0005176; F:ErbB-2 class receptor binding; TAS:UniProtKB
GO:0005178; F:integrin binding; IPI:UniProtKB
GO:0005200; F:structural constituent of cytoskeleton; NAS:UniProtKB
GO:0045175; P:basal protein localization; NAS:UniProtKB
GO:0007155; P:cell adhesion; NAS:UniProtKB
GO:0007049; P:cell cycle; NAS:UniProtKB
GO:0016049; P:cell growth; NAS:UniProtKB
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB
GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; NAS:UniProtKB
GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB
GO:0045104; P:intermediate filament cytoskeleton organization; NAS:UniProtKB
GO:0007165; P:signal transduction; TAS:ProtInc
Interpro
InterPro; IPR001611; Leu-rich_rpt
InterPro; IPR025875; Leu-rich_rpt_4
InterPro; IPR001478; PDZ
Pfam
Pfam; PF12799; LRR_4;
Pfam; PF13855; LRR_8;
Pfam; PF00595; PDZ;
SMART
SMART; SM00228; PDZ;
PROSITE
PROSITE; PS51450; LRR;
PROSITE; PS50106; PDZ;
PRINTS