LipidDB-9606-00954

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00954

Entry Name

TP4A1_HUMAN

UniProt Accession

Q93096; B2R6C8; O00648; Q49A54;

Theoretical PI

9.17

Molecular Weight

19815.08

Genbank Protein ID

AAB40597.1; AAC39836.1; BAG35425.1; CAH18292.1; CAC12761.1; EAW88494.1; AAH23975.1; AAH45571.1; AAB09080.1;

Genbank Nucleotide ID

U48296; AF051160; AK312526; CR749458; AL135905; CH471143; BC023975; BC045571; U69701;

Protein Name

Protein tyrosine phosphatase type IVA 1

Protein Synonyms/Alias

3.1.3.48; PTP(CAAXI); Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1;

Gene Name

PTP4A1

Gene Synonyms/Alias

PRL1; PTPCAAX1;

Created Date

05-JUL-2005

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
170	Canonical	SNGHRNNCCIQ****	[1]	S-Farnesylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, CrowellPL, Crowell DN. Prenylation of oncogenic human PTP(CAAX) protein tyrosinephosphatases. Cancer Lett. 1996 Dec 20;110(1-2):49-55.[PMID:9018080]

Functional Description

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Sequence Annotation

Domain: 82 148 Tyrosine-protein phosphatase.
Region: 97 132 Interaction with ATF5.
Region: 105 110 Phosphate binding.
Active site: 72 72 Proton donor.
Active site: 104 104 Phosphocysteine intermediate.
Binding site: 110 110 Substrate.
Modified residue: 170 170 Cysteine methyl ester.

Protein Length

173 AA.

Protein Sequence
(Canonical)

MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK  60
EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI  120
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ         173

FASTA
(Canonical)

>LipidDB-9606-00954|Q93096
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK
EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI
EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0009898; C:cytoplasmic side of plasma membrane; IDA:UniProtKB
GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005634; C:nucleus; IEA:Ensembl
GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW
GO:0030335; P:positive regulation of cell migration; IEA:Ensembl

Interpro

InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt

Pfam

Pfam; PF00102; Y_phosphatase;

SMART

PROSITE

PROSITE; PS50056; TYR_PHOSPHATASE_2;

PRINTS