LipidDB ID

LipidDB-9606-00944

Entry Name

UniProt Accession

P25101; B2R723; B4E2V6; B7Z9G6; D3DP03; E7ER36; O43441; Q16432; Q16433; Q8TBH2;

Theoretical PI

8.73

Molecular Weight

48722.24

Genbank Protein ID

AAB20278.1; AAB20407.1; CAA43953.1; BAA14359.1; AAB25530.2; AAA58447.1; BAA01920.1; AAB23644.1; AAB36325.1; AAB36326.1; AAB36327.1; AAP32294.1; AAQ87880.1; BAG65268.1; BAG35670.1; BAH14302.1; EAX05019.1; EAX05021.1; AAH22511.1; AAB25212.1; AAB94859.1;

Genbank Nucleotide ID

S63938; S67127; X61950; D90348; S57498; L06622; D11151; S45956; S81539; S81542; S81545; AY275462; AY422989; AK304451; AK312812; AK315931; AC093908; CH471056; CH471056; BC022511; S55772; AF014826;

Protein Name

Endothelin-1 receptor

Protein Synonyms/Alias

Endothelin A receptor; ET-A; ETA-R; hET-AR;

Gene Name

EDNRA

Gene Synonyms/Alias

ETA; ETRA;

Created Date

01-MAY-1992

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Stannard C, Lehenkari P, Godovac-Zimmermann J. Functional diversity ofendothelin pathways in human lung fibroblasts may be based on structuraldiversity of the endothelin receptors. Biochemistry. 2003 Dec 2;42(47):13909-18.[PMID:14636059]
[2] Kawanabe Y, Okamoto Y, Hashimoto N, Masaki T. Molecular mechanisms foractivation of voltage-independent Ca2+ channels by endothelin-1/endothelin-Areceptors. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S219-23.[PMID:15838284]

Functional Description

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Sequence Annotation

Topological domain: 21 80 Extracellular.
Transmembrane: 81 102 Helical; Name=1.
Topological domain: 103 112 Cytoplasmic.
Transmembrane: 113 132 Helical; Name=2.
Topological domain: 133 159 Extracellular.
Transmembrane: 160 181 Helical; Name=3.
Topological domain: 182 205 Cytoplasmic.
Transmembrane: 206 229 Helical; Name=4.
Topological domain: 230 256 Extracellular.
Transmembrane: 257 278 Helical; Name=5.
Topological domain: 279 306 Cytoplasmic.
Transmembrane: 307 328 Helical; Name=6.
Topological domain: 329 347 Extracellular.
Transmembrane: 348 372 Helical; Name=7.
Topological domain: 373 427 Cytoplasmic.

Protein Length

427 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0031965; C:nuclear membrane; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0030315; C:T-tubule; IEA:Ensembl
GO:0004962; F:endothelin receptor activity; NAS:UniProtKB
GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc
GO:0007190; P:activation of adenylate cyclase activity; TAS:ProtInc
GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc
GO:0007568; P:aging; IEA:Ensembl
GO:0014824; P:artery smooth muscle contraction; IMP:BHF-UCL
GO:0008283; P:cell proliferation; NAS:UniProtKB
GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl
GO:0086100; P:endothelin receptor signaling pathway; NAS:GOC
GO:0048484; P:enteric nervous system development; IEA:InterPro
GO:0048144; P:fibroblast proliferation; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB
GO:0003094; P:glomerular filtration; IEA:Ensembl
GO:0015758; P:glucose transport; ISS:UniProtKB
GO:0060322; P:head development; IEA:Ensembl
GO:0007507; P:heart development; IEA:Ensembl
GO:0001821; P:histamine secretion; IEA:Ensembl
GO:0001701; P:in utero embryonic development; IEA:Ensembl
GO:0060137; P:maternal process involved in parturition; IEA:Ensembl
GO:0008152; P:metabolic process; TAS:GOC
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0030818; P:negative regulation of cAMP biosynthetic process; IEA:Ensembl
GO:0014032; P:neural crest cell development; IEA:Ensembl
GO:0001569; P:patterning of blood vessels; IEA:Ensembl
GO:0043084; P:penile erection; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc
GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl
GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl
GO:0090184; P:positive regulation of kidney development; IEA:Ensembl
GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl
GO:0042482; P:positive regulation of odontogenesis; IEA:Ensembl
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl
GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl
GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0008217; P:regulation of blood pressure; IEA:InterPro
GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl
GO:0007585; P:respiratory gaseous exchange; ISS:UniProtKB
GO:0001666; P:response to hypoxia; IEA:Ensembl
GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl
GO:0043278; P:response to morphine; IEA:Ensembl
GO:0007266; P:Rho protein signal transduction; IEA:Ensembl
GO:0019233; P:sensory perception of pain; IEA:Ensembl
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0048659; P:smooth muscle cell proliferation; IEA:Ensembl
GO:0006939; P:smooth muscle contraction; NAS:UniProtKB
GO:0042310; P:vasoconstriction; IMP:BHF-UCL

Interpro

InterPro; IPR000499; Endthln_rcpt
InterPro; IPR002175; ETA_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00570; ENDOTHELINAR;
PRINTS; PR00366; ENDOTHELINR;
PRINTS; PR00237; GPCRRHODOPSN;