LipidDB ID

LipidDB-9606-00942

Entry Name

UniProt Accession

P01111; Q14971; Q15104; Q15282;

Theoretical PI

5.01

Molecular Weight

21229.17

Genbank Protein ID

CAA26529.1; CAA25269.1; CAA25270.1; CAA25271.1; CAA25272.1; AAA60255.1; AAA60255.1; AAA60255.1; AAA60255.1; AAM12633.1; AAQ94397.1; AAH05219.1; AAA36548.1; CAA37384.1; CAA37384.1; AAA36556.1; AAA36556.1; CAA29079.1; CAA30320.1;

Genbank Nucleotide ID

X02751; X00642; X00643; X00644; X00645; L00043; L00040; L00041; L00042; AF493919; AY428630; BC005219; M25898; X53291; X53292; K03211; M10055; X05565; X07440;

Protein Name

GTPase NRas

Protein Synonyms/Alias

Transforming protein N-Ras;

Gene Name

NRAS

Gene Synonyms/Alias

HRAS1;

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Hancock JF, Magee AI, Childs JE, Marshall CJ. All ras proteins arepolyisoprenylated but only some are palmitoylated. Cell. 1989 Jun30;57(7):1167-77.[PMID:2661017]
[2] Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M, Kuhlmann J,Waldmann H, Wittinghofer A, Bastiaens PI. An acylation cycle regulateslocalization and activity of palmitoylated Ras isoforms. Science. 2005 Mar18;307(5716):1746-52. Epub 2005 Feb 10.[PMID:15705808]
[3] Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME.DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificityfor H- and N-Ras. J Biol Chem. 2005 Sep 2;280(35):31141-8. Epub 2005 Jul 6.[PMID:16000296]

Functional Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 186 186 Cysteine methyl ester.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0032403; F:protein complex binding; IDA:MGI
GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl
GO:0000186; P:activation of MAPKK activity; TAS:Reactome
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome
GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0045087; P:innate immune response; TAS:Reactome
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome
GO:0050900; P:leukocyte migration; TAS:Reactome
GO:0000165; P:MAPK cascade; TAS:Reactome
GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0048642; P:negative regulation of skeletal muscle tissue development; IEA:Ensembl
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0035022; P:positive regulation of Rac protein signal transduction; IEA:Ensembl
GO:0007265; P:Ras protein signal transduction; TAS:Reactome
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl
GO:0008542; P:visual learning; IEA:Ensembl

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;