LipidDB ID

LipidDB-9606-00941

Entry Name

UniProt Accession

P01112; B5BUA0; Q14080; Q6FHV9; Q9BR65; Q9UCE2;

Theoretical PI

5.16

Molecular Weight

21298.13

Genbank Protein ID

AAB02605.1; CAD24594.1; AAM12630.1; CAG38816.1; CAG47067.1; AAV38228.1; ABI97389.1; BAG70150.1; BAG70299.1; EAX02337.1; EAX02338.1; AAH06499.1; AAH95471.1; AAA35685.1;

Genbank Nucleotide ID

J00277; AJ437024; AF493916; CR536579; CR542271; BT019421; EF015887; AB451336; AB451485; CH471158; CH471158; BC006499; BC095471; M17232;

Protein Name

GTPase HRas, N-terminally processed

Protein Synonyms/Alias

H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras;

Gene Name

HRAS

Gene Synonyms/Alias

HRAS1;

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Hancock JF, Magee AI, Childs JE, Marshall CJ. All ras proteins arepolyisoprenylated but only some are palmitoylated. Cell. 1989 Jun30;57(7):1167-77.[PMID:2661017]
[2] Forrester MT, Hess DT, Thompson JW, Hultman R, Moseley MA, Stamler JS, CaseyPJ. Site-specific analysis of protein S-acylation by resin-assisted capture. JLipid Res. 2011 Feb;52(2):393-8. doi: 10.1194/jlr.D011106. Epub 2010 Nov 2.[PMID:21044946]
[3] Dudler T, Gelb MH. Palmitoylation of Ha-Ras facilitates membrane binding,activation of downstream effectors, and meiotic maturation in Xenopus oocytes. J Biol Chem. 1996 May 10;271(19):11541-7.[PMID:8626715]

Functional Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 1 1 N-acetylmethionine; in GTPase HRas;alternate.
Modified residue: 2 2 N-acetylthreonine; in GTPase HRas, N-terminally processed.
Modified residue: 118 118 S-nitrosocysteine.
Modified residue: 186 186 Cysteine methyl ester.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; TAS:ProtInc
GO:0005829; C:cytosol; TAS:Reactome
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB
GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl
GO:0000186; P:activation of MAPKK activity; TAS:Reactome
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0007050; P:cell cycle arrest; IDA:BHF-UCL
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc
GO:0090398; P:cellular senescence; IDA:BHF-UCL
GO:0006935; P:chemotaxis; TAS:ProtInc
GO:0006897; P:endocytosis; IEA:Ensembl
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome
GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0045087; P:innate immune response; TAS:Reactome
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome
GO:0097193; P:intrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0050900; P:leukocyte migration; TAS:Reactome
GO:0000165; P:MAPK cascade; TAS:Reactome
GO:0007093; P:mitotic cell cycle checkpoint; IDA:BHF-UCL
GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl
GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL
GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0034259; P:negative regulation of Rho GTPase activity; IDA:BHF-UCL
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0009887; P:organ morphogenesis; TAS:ProtInc
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IDA:BHF-UCL
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL
GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL
GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:BHF-UCL
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL
GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL
GO:0043406; P:positive regulation of MAP kinase activity; IDA:BHF-UCL
GO:0043410; P:positive regulation of MAPK cascade; IDA:BHF-UCL
GO:2000630; P:positive regulation of miRNA metabolic process; IDA:BHF-UCL
GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL
GO:0032855; P:positive regulation of Rac GTPase activity; IDA:BHF-UCL
GO:0035022; P:positive regulation of Rac protein signal transduction; IEA:Ensembl
GO:1900029; P:positive regulation of ruffle assembly; IDA:BHF-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL
GO:0090303; P:positive regulation of wound healing; IDA:BHF-UCL
GO:0051291; P:protein heterooligomerization; IEA:Ensembl
GO:0007265; P:Ras protein signal transduction; IDA:BHF-UCL
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl
GO:0007165; P:signal transduction; NAS:ProtInc
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
GO:0035176; P:social behavior; IEA:Ensembl
GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0008542; P:visual learning; IEA:Ensembl

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;