LipidDB ID

LipidDB-9606-00939

Entry Name

UniProt Accession

Q15382; B3KWN6; D3DX13; Q53Y56; Q99444;

Theoretical PI

5.65

Molecular Weight

20497.49

Genbank Protein ID

CAA82774.1; BAA11211.1; AAF73125.1; AAM12635.1; BAG54198.1; AAP35604.1; AAD15548.1; EAW53989.1; AAH16155.1; AAI07706.1;

Genbank Nucleotide ID

Z29677; D78132; AF148645; AF493921; AK125446; BT006958; AC005996; CH471173; BC016155; BC107705;

Protein Name

GTP-binding protein Rheb

Protein Synonyms/Alias

Ras homolog enriched in brain;

Gene Name

RHEB

Gene Synonyms/Alias

RHEB2;

Created Date

30-MAY-2000

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C,Tamanoi F, Falck J, Zhao Y. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A. 2004 Aug24;101(34):12479-84. Epub 2004 Aug 12.[PMID:15308774]

Functional Description

Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 16 21 GTP.
Nucleotide-binding: 32 38 GTP.
Nucleotide-binding: 119 122 GTP.
Nucleotide-binding: 149 150 GTP.
Motif: 35 43 Effector region.
Metal binding site: 20 20 Magnesium.
Metal binding site: 38 38 Magnesium.
Modified residue: 130 130 Phosphoserine; by MAPKAPK5.
Modified residue: 181 181 Cysteine methyl ester.

Protein Length

184 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome
GO:0030425; C:dendrite; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016020; C:membrane; TAS:ProtInc
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005681; C:spliceosomal complex; IEA:Ensembl
GO:0019003; F:GDP binding; IEA:Ensembl
GO:0005525; F:GTP binding; ISS:UniProtKB
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0007050; P:cell cycle arrest; TAS:Reactome
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome
GO:0032008; P:positive regulation of TOR signaling; IMP:UniProtKB
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;